Anti-GITR antibodies and uses thereof
Provided herein are antibodies, and antigen-binding fragments thereof that specifically bind glucocorticoid-induced tumor necrosis factor receptor (GITR) and methods of using the same, including, e.g., methods of treatment using the same.
1. An Isolated antibody or antigen-binding fragment thereof that binds glucocorticoid-induced tumor necrosis factor receptor (GITR), wherein the antibody or antigen-binding fragment thereof comprises a heavy chain complementarity determining region (HCDR)-1 comprising SEQ ID NO: 340, an HCDR2 comprising SEQ ID NO: 342, and an HCDR3 comprising SEQ ID NO: 344, and a light chain complementarity determining region (LCDR)-1 comprising SEQ ID NO: 404, an LCDR2 comprising SEQ ID NO: 406, and an LCDR3 comprising SEQ ID NO: 408.
2. The isolated antibody or antigen-binding fragment thereof of claim 1 , wherein the antibody or antigen-binding fragment thereof comprises an HCVR having the amino acid sequence of SEQ ID NO: 338 and an LCVR having the amino acid sequence of SEQ ID NO: 402.
3. A pharmaceutical composition comprising the antibody or antigen-binding fragment thereof of claim 1 and a pharmaceutically acceptable carrier or diluent.
4. The antibody or antigen-binding fragment thereof of claim 1 , which is an antibody, comprising:
an HCDR-1 comprising SEQ ID NO: 340; an HCDR2 comprising SEQ ID NO: 342; an HCDR3 comprising SEQ ID NO: 344; an LCDR-1 comprising SEQ ID NO: 404; an LCDR2 comprising SEQ ID NO: 406; and an LCDR3 comprising SEQ ID NO: 408.