IP Library › Granted Patent US 10,737,084
Granted Patent B2
US 10,737,084 · App. 15/627,422 · Granted Aug 11, 2020

Drainage devices and methods for use

Inventors: Matthew J. Callaghan (Stanford, CA); Joelle A. Faulkner (Toronto, CA); Kevin Zi Jun Chao (Palo Alto, CA); John Avi Roop (Menlo Park, CA); Stephen Arie Leeflang (Sunnyvale, CA); Christian Scott Eversull (Palo Alto, CA)
Assignees: The Board of Trustees of the Leland Stanford Junior University; LXS, LLC
A61M39/0247A61B5/0215A61B5/036A61B5/14539A61B5/41A61B5/413A61M25/01A61B5/418A61F2/064A61F2/82A61F2002/061A61M27/002A61M2025/0057A61M2025/0197A61M2039/0258A61M2039/0276A61M2039/0291A61M2039/0297A61M2202/0405A61M2230/208
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Quick Facts
Patent No.
US 10,737,084
App. No.
15/627,422
Granted
Aug 11, 2020
Kind
B2
Abstract

Devices and methods for draining excess lymph fluid are disclosed. The device can be fixed to the blood vessel adjacent to the thoracic duct. The device can have a port for withdrawing lymph fluid exiting the thoracic duct. The device can have a cannula and/or subcutaneous port to draw the lymph fluid away from the thoracic duct and reduce hemostatic pressure in the lymphatic system.

Claims (26)

1. A method for reducing interstitial volume in a patient's body via a thoracic duct communicating with a venous system of the patient's body using a tubular member comprising a proximal end including an access port and a distal end, the method comprising:

implanting the tubular member into the venous system such that the distal end is located adjacent the thoracic duct and the access port is accessible;

expanding an expandable member on the distal end to isolate the thoracic duct from the venous system;

accessing the access port using a device outside the patient's body;

draining fluid from the thoracic duct through a lumen of the tubular member and the device to a location outside the patient's body to reduce fluid volume within the patient's body; and

discontinuing draining fluid and removing the device from the access port when the fluid volume is sufficiently reduced,

wherein the distal end of the tubular member is located outside the thoracic duct.

2. The method of claim 1 , further comprising applying negative pressure to the lumen to increase fluid flow from the thoracic duct through the tubular member.

3. The method of claim 1 , wherein the expandable member comprises one or more balloons on the distal end of the tubular member, the method further comprising inflating the one or more balloons to maintain the tubular member in a substantially fixed position relative to the thoracic duct.

4. The method of claim 1 , wherein the device comprises a Nitinol frame on the distal end, the method comprising expanding the frame to maintain the distal end in a substantially fixed position relative to the thoracic duct.

5. The method of claim 1 , wherein accessing the access port comprises cannulating the tubular member with the device.

6. The method of claim 1 , wherein the tubular member is implanted through an incision in a chest of the patient's body.

7. The method of claim 1 , wherein the device comprises a needle.

8. The method of claim 1 , wherein the access port is implanted subcutaneously in the patient's body.

9. The method of claim 1 , wherein the expandable member comprises one or more balloons on the distal end.

10. The method of claim 1 , further comprising:

reaccessing the access port using a device outside the patient's body; and

draining fluid from the thoracic duct through a lumen of the tubular member and the device to a location outside the patient's body to further reduce fluid volume within the patient's body.

11. A method for decreasing lymphocyte numbers in a patient's body affected by autoimmune or infectious disease via a thoracic duct communicating with a venous system of the patient's body using a tubular member comprising a proximal end including an access port and a distal end, the method comprising:

implanting the tubular member into the venous system such that the distal end is located adjacent the thoracic duct and the access port is accessible;

expanding an expandable member on the distal end to isolate the thoracic duct from the venous system;

accessing the access port using a device outside the patient's body;

draining fluid from the thoracic duct through a lumen of the tubular member and the device to a location outside the patient's body,

wherein the distal end of the tubular member is located outside the thoracic duct.

12. The method of in claim 11 , wherein a port on the distal end of the tubular member is aligned with an outlet of the thoracic duct such that flow from the thoracic duct is directed through the tubular member to drain fluid from the thoracic duct.

13. The method of claim 11 , wherein the expandable member comprises one or more balloons on the distal end of the tubular member, the method further comprising inflating the one or more balloons to maintain the tubular member in a substantially fixed position relative to the thoracic duct.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 5, 2020
From: LEEFLANG, STEPHEN ARIE; EVERSULL, CHRISTIAN SCOTT
To: LXS, LLC
Reel/Frame 052577/0289 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2017
From: CALLAGHAN, MATTEW J; FAULKNER, JOELLE A.; JUN CHAO, KEVIN Z.; ROOP, JOHN A.; THORSELL, ERIC
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY
Reel/Frame 042819/0055 →
Continuity (4)
Continuation 13179452 · Jul 8, 2011
Continuation In Part PCTUS2010000073 · Jan 12, 2010
Provisional Application 61204893 · Jan 12, 2009
Related Publication 20170354812A1 · Dec 14, 2017