Bakuchiol compositions for treatment of post inflammatory hyperpigmentation
Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.
1. A method for alleviating, reducing or treating excess pigmentation in a deep layer of skin resulting from post inflammatory hyperpigmentation derived from acne, the method comprising administering to a mammal an effective amount of a composition comprising bakuchiol, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier and less than 500 ppm total furanocoumarin impurities.
2. The method of claim 1 , wherein the composition comprises less than 100 ppm total furanocoumarin impurities.
3. The method of claim 1 , wherein the composition shows no tyrosinase inhibition activity relative to a kojic acid control.
4. The method of claim 1 , wherein the furanocoumarin impurities comprise psoralen, isopsoralen or combinations thereof.
5. The method of claim 1 , wherein the composition comprises 0.001% to 99.9% by total weight of bakuchiol and a pharmaceutically, dermatologically or cosmetically acceptable carrier.
6. The method of claim 1 , wherein the composition is administered topically, by aerosol, by suppository, intradermically, intramuscularly or intravenously.
7. The method of claim 1 , wherein the composition is formulated for topical administration.
8. The method of claim 1 , wherein the composition comprises from about 0.1% to about 2.0% by total weight of bakuchiol.
9. The method of claim 1 , wherein the composition comprises about 0.5% by total weight of bakuchiol.
10. The method of claim 1 , wherein the method alleviates excess pigmentation.
11. The method of claim 1 , wherein the method reduces excess pigmentation.
12. The method of claim 1 , wherein the method treats excess pigmentation.
13. The method of claim 1 , wherein the excess pigmentation occurs in a papillary dermis layer of skin.
14. The method of claim 1 , further comprising reducing super oxide anion.
15. The method of claim 1 , further comprising reducing melanogenesis.
16. The method of claim 1 , further comprising reducing melanocyte proliferation.
17. The method of claim 1 , further comprising reducing melanocyte apoptosis.
18. The method of claim 1 , wherein the composition further comprises salicylic acid or a pharmaceutically acceptable salt thereof.
19. A method for reducing melanogenesis, reducing melanocyte proliferation or reducing melanocyte apoptosis, wherein the melanogenesis, the melanocyte proliferation, or the melanocyte apoptosis is a result of post inflammatory hyperpigmentation in a deep layer of skin derived from acne, the method comprising administering to a mammal an effective amount of a composition comprising bakuchiol or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier and less than 500 ppm total furanocoumarin impurities.