Contrast agents for myocardial perfusion imaging
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
1. A compound having the structure:
2. A composition, comprising:
the compound of claim 1 and a solvent.
3. A compound having the structure:
4. A composition comprising:
the compound of claim 3 and a solvent.
5. A precursor compound to a 18 F labeled contrast agent of formula:
wherein the precursor compound has the formula:
and L G is a leaving group that can be replaced in an S N 2 displacement reaction to produce the 18 F labeled contrast agent.
6. The precursor compound of claim 5 , wherein the precursor compound is provided in a solution.
7. The precursor compound of claim 5 , wherein the precursor compound is provided as a solid preparation.
8. The precursor compound of claim 7 , wherein the solid preparation is a lyophilized solid.