IP Library › Granted Patent US 10,703,822
Granted Patent B2
US 10,703,822 · App. 15/630,020 · Granted Jul 7, 2020

Anti-inflammatory agents

Inventors: Jozef Maria Hendrik Raats (Nijmegen, NL); Renato Gerardus Silvano Chirivi (Oosterhout, NL)
Assignee: MODIQUEST B.V.
C07K16/40A61K39/3955A61K45/06C07K14/4713C07K16/18C07K16/44A61K2039/505C07K2317/21C07K2317/34C07K2317/56C07K2317/622C07K2317/92
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Quick Facts
Patent No.
US 10,703,822
App. No.
15/630,020
Granted
Jul 7, 2020
Kind
B2
Abstract

This invention is in the field of treating or preventing inflammation in humans and animals and relates to pharmaceutical compositions and methods for treating or preventing various inflammatory conditions. In particular, the invention relates to compositions and methods for treating or preventing inflammatory conditions such as citrulline-related inflammatory diseases. The invention provides specific binding molecules directed against citrulline-containing epitopes for use in the therapy and prevention of inflammatory conditions.

Claims (5)

1. A method of treating rheumatoid arthritis in a subject diagnosed with rheumatoid arthritis, the method comprising:

administering to the subject an antibody that binds a citrullinated epitope on the peptide of SEQ ID NO: 24.

2. The method according to claim 1 , wherein the antibody is RhmAb2.102.

3. The method according to claim 1 , wherein the antibody is a monoclonal antibody, a recombinant antibody, or a single chain antibody.

4. The method according to claim 1 , wherein the antibody comprises the variable heavy chain of SEQ ID NO: 13 and the variably light chain of SEQ ID NO: 15.

Assignments (4)
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY NAME PREVIOUSLY RECORDED AT REEL: 055893 FRAME: 0281. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER . Recorded Apr 14, 2021
From: CITRYLL IP B.V.
To: CITRYLL B.V.
Reel/Frame 055942/0235 →
MERGER Recorded Apr 12, 2021
From: CITRYLL IP B.V.
To: CITRYLL IP B.V.
Reel/Frame 055893/0281 →
DE-MERGER Recorded Apr 12, 2021
From: MODIQUEST B.V.
To: CITRYLL IP BV
Reel/Frame 055901/0828 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 10, 2017
From: RAATS, JOZEF MARIA HENDRIK; CHIRIVI, RENATO GERARDUS SILVANO
To: MODIQUEST B.V.
Reel/Frame 042955/0901 →
Priority Claims (3)
EP 08157547 · Jun 4, 2008 · regional
EP 08171920 · Dec 17, 2008 · regional
EP 09155484 · Mar 18, 2009 · regional
Continuity (2)
Continuation 12737075
Related Publication 20170298146A1 · Oct 19, 2017