Reduction of tooth staining derived from cationic antibacterials
Disclosed are oral care compositions having reduced tooth staining propensity and comprising in a pharmaceutically acceptable carrier, a cationic antimicrobial agent and an anti-stain agent comprising one or more materials from each of at least two of the following chemical groups: Group 1. anionic agents, Group 2. aldehydes, ketones, and other reactive carbonyl compounds and Group 3. nonionic ethoxylated surfactants. Examples of cationic antimicrobial agent include quaternary ammonium compounds such as cetylpyridinium chloride, cetyl pyridinium fluoride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride and domiphen bromide; chlorhexidine; and metal ion sources to supply metal ions such as stannous, zinc or copper.
1. A dentifrice composition, comprising:
a. stannous fluoride;
b. sodium lauryl sulfate;
c. from about 2% to about 30%, by weight of the dentifrice composition, of a polyphosphate selected from the group consisting of dialkali or tetraalkali metal pyrophosphate salts, tripolyphosphate, and mixtures thereof;
d. from about 0.04% to about 2%, by weight of the composition, of a flavoring agent comprising 4-methoxybenzaldehyde (anisaldehyde); 1,3-benzodioxole-5-carbaldehyde (heliotropin); 3,4-dimethoxybenzaldehyde (veratraldehyde); 3-methyl-1,2-cyclopentadione; phenethyl formate; acetophenone; phenylacetaldehyde; 4-methylacetophenone; ρ-toluacetaldehyde; 3,5,5-trimethyl-2-cyclohexene-1-one (isophorone); gamma-undecalactone; ρ-methyl cinnamaldehyde; 4-phenyl-2-butanone (benzyl acetone); octanal; 6-isopropyl-3-methyl-1-cyclohex-2-enone (piperitone); (S)-4-(1-methylethenyl)-1-cyclohexene-1-carboxaldehyde (perillaldehyde); 4-(1-methylethyl) benzaldehyde (cuminaldehyde); α-methyl cinnamaldehyde; isomenthone; menthone; carvone; decanal; 3-hydroxy-2-methyl-4H-pyran-4-one (maltol); or combinations thereof;
wherein the polyphosphate is the only source of polyphosphate in the dentifrice composition, and wherein the dentifrice composition has a percent reduction in stain from the stannous fluoride of at least about 40%.
2. The dentifrice composition according to claim 1 , wherein the dentifrice composition is a single phase composition.
3. The dentifrice composition according to claim 2 , wherein the flavoring agent comprises 4-methoxybenzaldehyde (anisaldehyde); α-methyl cinnamaldehyde; isomenthone; menthone; carvone; decanal; or combinations thereof.
4. The dentifrice composition according to claim 2 , wherein the dentifrice composition comprises saccharin.
5. The dentifrice composition according to claim 2 , wherein the dentifrice composition comprises from about 0.25% to 5%, by weight of the composition, of titanium dioxide.
6. The dentifrice composition according to claim 1 , wherein the dentifrice composition comprises from about 0.05% to about 5%, by weight of the composition, of the sodium lauryl sulfate.
7. The dentifrice composition according to claim 1 , wherein the dentifrice composition comprises from about 10% to about 50%, by weight of the composition, of a silica abrasive.
8. The dentifrice composition according to claim 1 , wherein the dentifrice composition comprises cocamidopropyl betaine.
9. The dentifrice composition of claim 1 , wherein the dentifrice composition comprises a thickening agent.
10. The dentifrice composition of claim 9 , wherein the thickening agent comprises a carboxyvinyl polymer, carrageenan, hydroxyethyl cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl hydroxyethyl cellulose, xanthan gum, acrylic-maleic acid copolymers, or combinations thereof.
11. A dentifrice composition, comprising:
a. stannous fluoride;
b. sodium lauryl sulfate;
c. a polyphosphate selected from the group consisting of dialkali or tetraalkali metal pyrophosphate salts, tripolyphosphate, and mixtures thereof;
d. from about 0.04% to about 2%, by weight of the composition, of a flavoring agent comprising 4-methoxybenzaldehyde (anisaldehyde); 1,3-benzodioxole-5-carbaldehyde (heliotropin); 3,4-dimethoxybenzaldehyde (veratraldehyde); 3-methyl-1,2-cyclopentadione; phenethyl formate; acetophenone; phenylacetaldehyde; 4-methylacetophenone; ρ-toluacetaldehyde; 3,5,5-trimethyl-2-cyclohexene-1-one (isophorone); gamma-undecalactone; ρ-methyl cinnamaldehyde; 4-phenyl-2-butanone (benzyl acetone); octanal; 6-isopropyl-3-methyl-1-cyclohex-2-enone (piperitone); (S)-4-(1-methylethenyl)-1-cyclohexene-1-carboxaldehyde (perillaldehyde); 4-(1-methylethyl) benzaldehyde (cuminaldehyde); α-methyl cinnamaldehyde; isomenthone; menthone; carvone; decanal; 3-hydroxy-2-methyl-4H-pyran-4-one (maltol); or combinations thereof; and
e. cocamidopropyl betaine;
wherein the polyphosphate is the only source of polyphosphate in the dentifrice composition and the dentifrice composition has a percent reduction in stain from the stannous fluoride of at least about 40%.
12. The dentifrice composition of claim 11 , wherein the flavoring agent comprises from 4-methoxybenzaldehyde (anisaldehyde); α-methyl cinnamaldehyde; isomenthone; menthone; carvone; decanal; or combinations thereof.
13. The dentifrice composition of claim 11 , wherein the dentifrice composition comprises a thickening agent, the thickening agent comprising a carboxyvinyl polymer, carrageenan, hydroxyethyl cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl hydroxyethyl cellulose, xanthan gum, acrylic-maleic acid copolymers, or combinations thereof.
14. The dentifrice composition of claim 13 , wherein the polyphosphate is a dialkali or tetraalkali metal pyrophosphate salt and the thickening agent comprises xanthan gum and sodium carboxymethyl cellulose.
15. The dentifrice composition of claim 14 , wherein the dentifrice composition comprises zinc phosphate.
16. The dentifrice composition of claim 13 , wherein the polyphosphate is tripolyphosphate and the thickening agent comprises carrageenan and xanthan gum.
17. The dentifrice composition of claim 16 , wherein the dentifrice composition comprises zinc oxide.
18. The dentifrice composition of claim 17 , wherein the dentifrice composition comprises zinc citrate.
19. A dentifrice composition, comprising:
a. stannous fluoride;
b. sodium lauryl sulfate;
c. a polyphosphate selected from the group consisting of pyrophosphate dialkali or tetraalkali metal pyrophosphate salts tripolyphosphate, and mixtures thereof;
d. a flavoring agent comprising anisaldehyde; and
e. cocamidopropyl betaine;
wherein the polyphosphate is the only source of polyphosphate in the dentifrice composition and the dentifrice composition has a percent reduction in stain from the stannous fluoride of at least about 40%.
20. The dentifrice composition of claim 19 , wherein the dentifrice composition comprises zinc phosphate, zinc oxide, zinc citrate, or combinations thereof.
21. The dentifrice composition of claim 20 , wherein the dentifrice composition comprises a thickening agent, the thickening agent comprising a carboxyvinyl polymer, carrageenan, hydroxyethyl cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl hydroxyethyl cellulose, xanthan gum, acrylic-maleic acid copolymers, or combinations thereof.
22. The dentifrice composition of claim 21 , wherein the polyphosphate is a dialkali or tetraalkali metal pyrophosphate salt and the thickening agent comprises xanthan gum and sodium carboxymethyl cellulose.
23. The dentifrice composition of claim 21 , wherein the polyphosphate is tripolyphosphate and the thickening agent comprises carrageenan and xanthan gum.