Microbiota restoration therapy (MRT), compositions and methods of manufacture
Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method may include a method of treating an infection. The method may comprise administering a microbiota restoration therapy composition to a patient with an infection. The microbiota restoration therapy composition may comprise a mixture of an effective amount of fecal microbiota and an effective amount of polyethylene glycol.
1. A method of treating an infection, the method comprising:
administering an antibiotic to a patient having an infection;
wherein the infection includes a vancomycin-resistant enterococci infection or a methicillin-resistant Staphylococcus aureus infection; and
after administering the antibiotic, administering a dose of a microbiota restoration therapy composition to the patient;
wherein the microbiota restoration therapy composition comprises a mixture of an effective amount of fecal microbiota from a fresh human fecal sample and polyethylene glycol at a concentration of 30-90 g/L.
2. The method of claim 1 , wherein the antibiotic includes vancomycin, fidaxomicin, rifaximimin, linezolid, daptomycin, quinupristin-dalfopristin, tigecycline, ceftaroline, ceftobiprole, televancin, teicoplanin, dalbavancin, metronidazole, ortivancin, or a combination thereof.
3. The method of claim 1 , further comprising after administering the dose of microbiota restoration therapy, administering a secondary dose of a microbiota restoration therapy composition.
4. The method of claim 1 , wherein administering the antibiotic comprises administering a primary antibiotic followed by a secondary antibiotic.
5. The method of claim 1 , further comprising after administering the dose of the microbiota restoration therapy composition, administering a secondary antibiotic.
6. The method of claim 1 , wherein administering a dose of a microbiota restoration therapy composition to the patient includes administering the microbiota restoration therapy composition with an enema tube.
7. The method of claim 1 , wherein administering a dose of a microbiota restoration therapy composition to the patient includes orally administering the microbiota restoration therapy composition.
8. A method of treating a drug resistant infection, the method comprising:
administering a primary antibiotic to a patient having an infection;
wherein the infection includes a vancomycin-resistant enterococci infection or a methicillin-resistant Staphylococcus aureus infection;
administering a secondary antibiotic to the patient with the infection;
after administering the primary and secondary antibiotics, administering a primary dose of a microbiota restoration therapy composition to the patient with the infection; and
wherein the microbiota restoration therapy composition comprises a mixture of an effective amount of fecal microbiota from a fresh human fecal sample and polyethylene glycol at a concentration of 30-90 g/L and is pre-screened for bacterial diversity.
9. The method of claim 8 , further comprising administering a secondary dose of a microbiota restoration therapy composition to the patient with the infection.
10. The method of claim 8 , further comprising administering a post-treatment antibiotic to the patient after administering the primary microbiota restoration therapy composition to the patient.
11. The method of claim 10 , wherein the primary antibiotic, secondary antibiotic, and/or post-treatment antibiotic includes vancomycin, fidaxomicin, rifaximimin, linezolid, daptomycin, quinupristin-dalfopristin, tigecycline, ceftaroline, ceftobiprole, televancin, teicoplanin, dalbavancin, metronidazole, ortivancin, or a combination thereof.
12. A method of treating a drug resistant infection, the method comprising:
administering a primary antibiotic to a patient having a drug resistant infection;
wherein the infection includes a vancomycin-resistant enterococci infection or a methicillin-resistant Staphylococcus aureus infection;
after administering the primary antibiotic, administering a primary dose of a microbiota restoration therapy composition to the patient with the infection;
administering a secondary dose of a microbiota restoration therapy composition to the patient; and
wherein the primary and/or secondary doses of microbiota restoration therapy composition comprises a mixture of an effective amount of fecal microbiota from a fresh human fecal sample and polyethylene glycol at a concentration of 30-90 g/L and is pre-screened for bacterial diversity.
13. The method of claim 12 , wherein administering a primary dose and/or a secondary dose of a microbiota restoration therapy composition to the patient includes administering the microbiota restoration therapy composition with an enema tube.
14. The method of claim 12 , wherein administering a primary dose and/or a secondary dose of a microbiota restoration therapy composition to the patient includes orally administering the microbiota restoration therapy composition.