IP Library Granted Patent US 10,428,160
Granted Patent B2
US 10,428,160 · App. 15/645,914 · Granted Oct 1, 2019

Colorimetric hydrogel based nanosensor for detection of therapeutic levels of ionizing radiation

Inventors: Kaushal Rege (Chandler, AZ); Karthik Subramaniam Pushpavanam (Tempe, AZ); Stephen Sapareto (Apache Junction, AZ)
Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY; BANNER HEALTH—An Arizona Nonprofit Corporation
C08B37/0039C08J3/075C08K3/08C08K3/30C08L5/12C01G7/00C08J2305/12C08K2003/0831C08K2003/3009G01J3/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,428,160
App. No.
15/645,914
Filed
Jul 10, 2017
Granted
Oct 1, 2019
Kind
B2
Art Unit
2884
USPC
250/474.1
Abstract

An apparatus includes a hydrogel including a metallic compound, a surfactant, an acid, agarose and water. The hydrogel is substantially colorless. A radiated hydrogel having a color is formed when the hydrogel receives a low dose of ionizing radiation.

Claims (15)

1. A composition of matter comprising a hydrogel including a metallic salt, a cationic surfactant, ascorbic acid, agarose, and water.

2. The composition of claim 1 , wherein the metallic salt comprises a gold salt.

3. The composition of claim 1 , wherein the metallic salt comprises a salt of auric chloride (HAuCl 4 ).

4. The composition of claim 1 , wherein the cationic surfactant comprises cetyl trimethammoniom bromide (C 16 TAB).

5. The composition of claim 1 , wherein the ascorbic acid comprises L-ascorbic acid.

6. An apparatus comprising:

a substantially colorless hydrogel to receive a low dose of radiation and form a radiated hydrogel having a color; and

a detector optically coupled to the radiated hydrogel, wherein the radiated hydrogel comprises a plasmonic nanoparticle.

7. An apparatus comprising:

a substantially colorless hydrogel to receive a low dose of radiation and form a radiated hydrogel having a color; and

a detector optically coupled to the radiated hydrogel, wherein the substantially colorless hydrogel comprises a metallic salt, a cationic surfactant, ascorbic acid, agarose, and water.

8. The apparatus of claim 7 , wherein the metallic salt comprises a gold salt.

9. The apparatus of claim 7 , wherein the metallic salt comprises a salt of auric chloride (HAuCl 4 ).

10. The apparatus of claim 7 , wherein the cationic surfactant comprises cetyl trimethammoniom bromide (C 16 TAB).

11. The apparatus of claim 7 , wherein the ascorbic acid comprises L-ascorbic acid.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 13, 2018
From: REGE, KAUSHAL; PUSHPAVANAM, KARTHIK SUBRAMANIAM
To: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Reel/Frame 047764/0915 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 13, 2018
From: SAPARETO, STEPHEN
To: BANNER HEALTH - AN ARIZONA NONPROFIT CORPORATION
Reel/Frame 047765/0043 →
CONFIRMATORY LICENSE Recorded Jul 27, 2017
From: ARIZONA STATE UNIVERSITY, TEMPE
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 043350/0884 →
Continuity (3)
Provisional Application 62490498 · Apr 26, 2017
Provisional Application 62360111 · Jul 8, 2016
Related Publication 20180066074A1 · Mar 8, 2018
Cited By (1)
US 12,663,562