IP Library › Patent Application 15646437
Patent Application
App. No. 15/646,437

METHOD OF ENHANCING MIR-185 EXPRESSION TO REDUCE LOW DENSITY LIPOPROTEIN/CHOLESTEROL ACCUMULATION IN A CELL

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Quick Facts
Patent No.
US None
App. No.
15/646,437
Abstract

The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans.

Claims (5)

1 . A kit for determining an increased risk for atherosclerosis in a human, comprising:

a) a reagent for quantifying miR-185 expression level in a biological sample; and

b) an instruction for use of said reagent in quantifying said miR-185 expression level, wherein an increased miR-185 expression level is indicative of an increased risk of atherosclerosis in a human.

2 . The kit of claim 1 , wherein said reagent comprises a forward primer and a reverse primer for miR-185 used in a qRT-PCR to specifically quantify the expression level of miR-185.

3 . The kit of claim 1 , wherein said biological sample is blood.

Assignments (1)
SECURITY INTEREST Recorded Apr 27, 2018
From: MEDICAL DIAGNOSTIC LABORATORIES, L.L.C.
To: TD BANK, N.A.
Reel/Frame 046031/0381 →