Controlled release active agent carrier
The present invention relates to carriers for the controlled release of active agents, comprising surface reacted natural or synthetic calcium carbonate, one or more active agents, wherein said one or more active agent is associated with said surface-reacted calcium carbonate, and wherein said surface-reacted natural or synthetic calcium carbonate is a reaction product of natural or synthetic calcium carbonate with carbon dioxide and one or more acids, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source. It further relates to the preparation of loaded carriers, as well as their use in different applications.
1. A method for preparing a loaded carrier comprising the steps of:
(a) providing surface reacted calcium carbonate in powder or granule form that is reaction product of calcium carbonate with carbon dioxide and one or more acids in an aqueous environment, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source,
(b) providing an active agent in the form of a prepared solution or suspension;
(c) contacting the surface reacted calcium carbonate with the active agent until a sufficient amount of the active agent is adsorbed onto and/or absorbed into the surface-reacted calcium carbonate; and
(d) separating the loaded carrier from excess solution or suspension.
2. The method according to claim 1 , wherein the calcium carbonate is natural calcium carbonate selected from the group consisting of marble, calcite, chalk, limestone, and any mixture thereof.
3. The method according to claim 1 , wherein the one or more acids is selected from the group consisting of hydrochloric acid, sulphuric acid, sulphurous acid, hydrosulphate, phosphoric acid, oxalic acid, and any mixture thereof.
4. The method according to claim 1 , wherein the one or more acids is phosphoric acid.
5. The method according to claim 1 , wherein the surface reacted calcium carbonate has a specific surface area of from 5 m 2 /g to 200 m 2 /g, measured using nitrogen and the BET method according to ISO 9277.
6. The method according to claim 1 , wherein the surface reacted calcium carbonate has a specific surface area of from 20 m 2 /g to 80 m 2 /g, measured using nitrogen and the BET method according to ISO 9277.
7. The method according to claim 1 , wherein the surface reacted calcium carbonate has a specific surface area of from 30 m 2 /g to 60 m 2 /g, measured using nitrogen and the BET method according to ISO 9277.
8. The method according to claim 1 , wherein the surface reacted calcium carbonate has a weight median grain diameter d 50 of from 0.1 to 50 μm, measured according to the sedimentation method.
9. The method according to claim 1 , wherein the surface reacted calcium carbonate has a weight median grain diameter d 50 of from 0.5 to 25 μm, measured according to the sedimentation method.
10. The method according to claim 1 , wherein the surface reacted calcium carbonate has a weight median grain diameter d 50 of from 0.8 to 20 μm, measured according to the sedimentation method.
11. The method according to claim 1 , wherein the surface reacted calcium carbonate has an intra-particle porosity determined as a pore volume per unit particle volume from 20 vol.-% to 99 vol.-%, calculated from a mercury porosimetry measurement.
12. The method according to claim 1 , wherein the surface reacted calcium carbonate has an intra-particle porosity determined as a pore volume per unit particle volume from 30 vol.-% to 70 vol.-%, calculated from a mercury porosimetry measurement.
13. The method according to claim 1 , wherein the surface reacted calcium carbonate has an intra-particle porosity determined as a pore volume per unit particle volume from 40 vol.-% to 60 vol.-%, calculated from a mercury porosimetry measurement.
14. The method according to claim 1 , wherein the loaded carrier is combined with one or more cosmetically acceptable carriers to obtain a cosmetic formulation in the form of a powder, a cream, an emulsion, a gel, a paste, a soap, a gum, or a tablet.
15. The method according to claim 14 , wherein the one or more active agents is selected from the group consisting of a pharmaceutical active agent, a biological active agent, a scented agent, a flavoring agent, a biocide, a disinfecting agent, a surfactant, a defoamer, a softener, a mineral oil, a wetting agent, a wax, a hydrolytic agent, and an anti-dusting oil.
16. The method according to claim 14 , wherein the one or more active agents is selected from the group consisting of triclosan, limonene, peppermint, silicon, paraffin, o-phenylphenol and Bronopol.
17. The method according to claim 14 , wherein the cosmetic formulation is a lipstick, a foundation, a deodorant, a sunscreen, a skin care formulation, a hair care product, a soap, a skin cream, a tooth paste, a bath additive, a foot powder, a facial powder, a sun screen, or a chewing gum.
18. The method according to claim 1 , wherein the loaded carrier is combined with one or more pharmaceutically acceptable carriers to obtain a pharmaceutical formulation in the form of a capsule, a tablet, a patch, or a cream.
19. The method according to claim 1 , wherein the loaded carrier is combined with one or more pharmaceutically acceptable carriers to obtain a pharmaceutical formulation in the form of a capsule, a tablet, a patch, or a cream.
20. The method according to claim 1 , wherein the loaded carrier is formulated into an agricultural formulation, and wherein the one or more active agents is selected from the group consisting of an agricultural agent, a biocide, a pesticide, and a herbicide.