IP Library Granted Patent US 10,213,392
Granted Patent B2
US 10,213,392 · App. 15/648,314 · Granted Feb 26, 2019

Pharmaceutical composition for use in medical and veterinary ophthalmology

Inventor: Maxim V. Skulachev (Moscow, RU)
Assignee: MITOTECH SA
A61K31/122A61K9/0048C09B69/001
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Quick Facts
Patent No.
US 10,213,392
App. No.
15/648,314
Granted
Feb 26, 2019
Kind
B2
Abstract

The invention relates to the manufacturing and use of pharmaceutical compositions of medicines (ophthalmic preparations) comprising a mitochondria-addressed antioxidant and a set of auxiliary substances providing effective treatment for ophthalmological diseases in humans and animals.

Claims (11)

1. A method of treating an eye pathology, comprising administering to a subject afflicted with such an eye pathology a therapeutically-effective amount of a pharmaceutical composition comprising:

(a) from 1 nm to 25000 nm of a mitochondria-addressed antioxidant comprising:

(b) from 0.01% to 0.2% of a lipophilic, cationic concentration stabilizer that stabilizes a concentration of the mitochondria-addressed antioxidant by preventing reversible and irreversible absorption of the antioxidant to walls of a vial containing the pharmaceutical composition, the stabilizer comprising a benzalkonium salt, berberine, palmatine, tetraphenylphosphonium, tetrabutyl ammonium, or combinations thereof; and

(c) from 0.001% to 1% of a prolongator comprising a disaccharide, a trisaccharide, a polysaccharide, methylcellulose, hydroxyethylcellulose, hydroxypropyl-methyl cellulose, carboxymethylcellulose, sodium chondroitin sulfate, sodium hyaluronate, carboxyvinyl polymer, polyvinyl ethanol, polyvinylpyrrolidone, macrogol, or combinations thereof.

2. The method of claim 1 , wherein the eye pathology is macular degeneration of the retina.

3. The method of claim 1 , wherein the eye pathology is cataract, senile cataract and/or diabetic cataract.

4. The method of claim 1 , wherein the eye pathology is a retinopathy.

5. The method of claim 4 , wherein the retinopathy is retinal detachment, detached retinal vessels, detached choroid, optic nerve retinopathy, optic nerve atrophy, central and peripheral chorioretinal dystrophies, or uveitis.

6. The method of claim 1 , wherein the eye pathology is intraocular hemorrhage or traumatic hemorrhage.

7. The method of claim 1 , wherein the eye pathology is conjunctivitis, eye ulcer, keratitis, or dry keratoconjunctivitis.

8. The method of claim 1 , wherein the eye pathology is glaucoma.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 13, 2023
From: MITOTECH S.A.
To: ESSEX BIO-INVESTMENT LIMITED
Reel/Frame 063312/0574 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2017
From: SKULACHEV, MAXIM V.
To: MITOTECH SA
Reel/Frame 044456/0442 →
Continuity (3)
Division 13315397 · Dec 9, 2011
Continuation In Part PCTRU2009000295 · Jun 10, 2009
Related Publication 20170304225A1 · Oct 26, 2017