IP Library › Granted Patent US 10,017,496
Granted Patent B2
US 10,017,496 · App. 15/649,526 · Granted Jul 10, 2018

Uracil derivatives as AXL and c-MET kinase inhibitors

Inventors: Reddeppa Reddy Dandu (San Diego, CA); Robert L. Hudkins (San Diego, CA); Kurt A. Josef (San Diego, CA); Catherine P. Prouty (San Diego, CA); Rabindranath Tripathy (San Diego, CA)
Assignee: IGNYTA, INC.
C07D401/12A61K31/4725A61K31/506A61K31/513A61K31/517A61K45/06C07D239/54C07D401/14C07D403/12C07D403/14C07D405/14C07D413/14C07D417/14C07D491/04C07D491/048C07D491/056
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Quick Facts
Patent No.
US 10,017,496
App. No.
15/649,526
Granted
Jul 10, 2018
Kind
B2
Abstract

The present invention provides compounds of Formula I or pharmaceutically acceptable salt forms thereof, wherein R a , R b , R c , R d , D, W, R 1a , R 1b , R 1c , Y, R 3 , X, E and G are as defined herein, methods of treatment and uses thereof.

Claims (2)

1. A compound of formula:

2. A compound of formula

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 8, 2017
From: DANDU, REDDEPPAREDDY; HUDKINS, ROBERT L.; JOSEF, KURT A.; PROUTY, CATHERINE P.; TRIPATHY, RABINDRANATH
To: CEPHALON, INC.
Reel/Frame 043235/0495 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 8, 2017
From: CEPHALON, INC.
To: IGNYTA, INC.
Reel/Frame 043235/0500 →
Continuity (6)
Continuation 15346582 · Nov 8, 2016
Continuation 14681974 · Apr 8, 2015
Continuation 14276138 · May 13, 2014
Continuation PCTUS2012065019 · Nov 14, 2012
Provisional Application 61559312 · Nov 14, 2011
Related Publication 20170320853A1 · Nov 9, 2017