Methods of Treating Prostate Cancer
Disclosed are methods of treating prostate cancer by administering niraparib to a human in need thereof.
1 . A method of treating prostate cancer in a human in need of such treatment comprising administering to the human a safe and effective amount of niraparib.
2 . A method of claim 1 , wherein the prostate cancer is castration-resistant prostate cancer or metastatic castration-resistant prostate cancer.
3 . A method of claim 2 , wherein the prostate cancer is antiandrogen resistant.
4 . A method as in claim 3 , wherein the human is carrying at least one DNA repair anomaly selected from the group consisting of BRCA-1, BRCA-2, FANCA, PALB2, CHEK2, HDAC2, and ATM.
5 . A method of claim 4 , where in the DNA repair anomaly is BRCA-1 or BRCA-2.
6 . A method of claim 5 , wherein the prostate cancer is castration-resistant prostate cancer.
7 . A method of claim 5 , wherein the prostate cancer is metastatic castration-resistant prostate cancer.
8 . A method of claim 6 , wherein niraparib is administered in an amount of from about 30 mg/day to about 400 mg/day.
9 . A method of claim 8 , wherein the amount of niraparib administered is about 300 mg/day.
10 . A method of claim 9 , wherein niraparib is administered as once daily oral administration in three 100 mg oral dosage forms.
11 . A method of treating castration and anti androgen resistant prostate cancer in a human comprising administering three 100 mg oral dosage forms niraparib once daily to the human.