Compounds and compositions and uses thereof
Disclosed are compounds of formula (I): and pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disease and disorders in a subject in need are also disclosed.
1. A compound, wherein said compound is:
or a pharmaceutically acceptable salt thereof.
2. A compound, wherein said compound is:
or a pharmaceutically acceptable salt thereof.
3. A method of treating a neurological or psychiatric disease or disorder selected from bipolar disorder, anxiety, depression, Alzheimer's Disease with agitation, Alzheimer's Disease with aggression or Alzheimer's Disease with agitation aggression in a subject in need thereof, comprising administering to said subject an effective amount of a compound selected from:
or a pharmaceutically acceptable salt thereof.
4. A method of treating bipolar disorder in a subject in need thereof, comprising administering to said subject an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
5. A method of treating anxiety in a subject in need thereof, comprising administering to said subject an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
6. A method of treating depression in a subject in need thereof, comprising administering to said subject an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
7. A method of treating Alzheimer's Disease with agitation in a subject in need thereof, comprising administering to said subject an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
8. A method of treating Alzheimer's Disease with aggression in a subject in need thereof, comprising administering to said subject an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
9. A method of treating Alzheimer's Disease with agitation aggression in a subject in need thereof, comprising administering to said subject an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
10. The compound according to claim 2 , wherein said compound is greater than 90% enantiomerically pure.
11. The compound according to claim 2 , wherein said compound is greater than 95% enantiomerically pure.
12. A compound, wherein said compound is:
or a pharmaceutically acceptable salt thereof.
13. The compound according to claim 12 , wherein said compound is greater than 90% enantiomerically pure.
14. The compound according to claim 12 , wherein said compound is greater than 95% enantiomerically pure.
15. A compound, wherein said compound is:
or a pharmaceutically acceptable salt thereof.
16. The compound according to claim 15 , wherein said compound is greater than 90% enantiomerically pure.
17. The compound according to claim 15 , wherein said compound is greater than 95% enantiomerically pure.
18. A compound, wherein said compound is:
19. The compound according to claim 18 , wherein said compound is greater than 90% enantiomerically pure.
20. The compound according to claim 18 , wherein said compound is greater than 95% enantiomerically pure.
21. A compound, wherein said compound is:
22. The compound according to claim 21 , wherein said compound is greater than 90% enantiomerically pure.
23. The compound according to claim 21 , wherein said compound is greater than 95% enantiomerically pure.
24. A pharmaceutical composition comprising the compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
25. A pharmaceutical composition comprising the compound according to claim 2 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
26. A pharmaceutical composition comprising the compound according to claim 12 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
27. A pharmaceutical composition comprising the compound according to claim 15 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
28. A pharmaceutical composition comprising the compound according to claim 18 , and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
29. A pharmaceutical composition comprising the compound according to claim 21 , and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
30. A method of treating Alzheimer's Disease in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
31. A method of treating bipolar disorder in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 12 , or a pharmaceutically acceptable salt thereof.
32. A method of treating anxiety in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 12 , or a pharmaceutically acceptable salt thereof.
33. A method of treating depression in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 12 , or a pharmaceutically acceptable salt thereof.
34. A method of treating Alzheimer's Disease in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 12 , or a pharmaceutically acceptable salt thereof.
35. A method of treating Alzheimer's Disease with agitation in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 12 , or a pharmaceutically acceptable salt thereof.
36. A method of treating Alzheimer's Disease with aggression in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 12 , or a pharmaceutically acceptable salt thereof.
37. A method of treating Alzheimer's Disease with agitation aggression in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 12 , or a pharmaceutically acceptable salt thereof.
38. A method of treating bipolar disorder in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 15 , or a pharmaceutically acceptable salt thereof.
39. A method of treating anxiety in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 15 , or a pharmaceutically acceptable salt thereof.
40. A method of treating depression in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 15 , or a pharmaceutically acceptable salt thereof.
41. A method of treating Alzheimer's Disease in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 15 , or a pharmaceutically acceptable salt thereof.
42. A method of treating Alzheimer's Disease with agitation in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 15 , or a pharmaceutically acceptable salt thereof.
43. A method of treating Alzheimer's Disease with aggression in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 15 , or a pharmaceutically acceptable salt thereof.
44. A method of treating Alzheimer's Disease with agitation aggression in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 15 , or a pharmaceutically acceptable salt thereof.