Heteroaryl amides as inhibitors of protein aggregation
The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.
1. A method of treating Parkinson's disease, comprising administering to a subject in need of such treatment an effective amount of a compound that is
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 . wherein the compound is:
or a pharmaceutically acceptable salt thereof.
4. The method of claim 1 , wherein Parkinson's disease is Parkinson's disease with dementia.