FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS
Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A 1 , A 2 , R 6 , w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
1 - 55 . (canceled)
56 . A process for preparing a compound of formula
as its hydrochloride salt, comprising:
combining
and di-tert-butyl dicarbonate in the presence of a base to form
resolving
into its enantiomers
and isolating
and deprotecting
to obtain
57 . A process according to claim 56 , wherein said resolving is accomplished by chiral HPLC.
58 . A process according to claim 56 , further comprising combining
with 4-methylbenzenesulfonic acid to obtain
59 . A process according to claim 58 , further comprising combining
with lithium diisopropylamide to form a mixture, then combining the mixture with tert-butyl methyl (2-oxoethyl)carbamate to obtain
60 . A process according to claim 58 , further comprising combining
in 2-bromoethanol to obtain
61 . A process for preparing a compound of formula
as its hydrochloride salt, comprising:
a) combining
in 2-bromoethanol to obtain
b) combining
with lithium diisopropylamide to form a mixture, then combining the mixture with tert-butyl methyl(2-oxoethyl)carbamate to obtain
c) combining
with 4-methylbenzenesulfonic acid to obtain
and
d) combining
and di-tert-butyl dicarbonate in the presence of a base to form
e) resolving
into its enantiomers
and isolating
and
f) deprotecting
to obtain
62 . A process according to claim 61 , wherein said resolving in step e) is accomplished by chiral HPLC.