Indole-based therapeutics
View Patent ↗Provided herein are indole-2-carboxamide compounds useful for the treatment of non-tuberculosis bacterial infections. Exemplary compounds provided herein are useful for the treatment of non-tuberculosis mycobacterial infections. Methods for preparing the indole-2-carboxamide compounds are also provided.
1. A method of treating a non-tuberculosis mycobacterial infection in a subject in need thereof, comprising identifying the subject as having a non-tuberculosis mycobacterial infection, and administering to the subject a therapeutically effective amount of a compound
selected from the group consisting of:
or a pharmaceutically acceptable salt thereof;
wherein the non-tuberculosis mycobacterium is selected from the group consisting of M abscessus, M. massiliense, M. bolletii, M. chelonae , and M. avium.
2. The method of claim 1 , wherein the non-tuberculosis mycobacterial infection is a hospital acquired mycobacterial infection.
3. The method of claim 1 , wherein the subject is further infected with a pathogen selected from Pseudomonas aeruginosa and Staphylococcus aureus , or a combination thereof.
4. The method of claim 1 , wherein the subject has been identified as having a lung disease.
5. The method of claim 4 , wherein the lung disease is selected from the group consisting of cystic fibrosis, bronchiectasis, emphysema, and chronic obstructive pulmonary disease, and bronchiectasis.
6. The method of claim 1 , wherein the subject is a pediatric subject.
7. The method of claim 1 , wherein the compound is selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
8. The method of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.