Pharmaceutical composition comprising botulinum, a non ionic surfactant, sodium chloride and sucrose
Solid and liquid pharmaceutical compositions comprising botulinum neurotoxin complex or high purity botulinum neurotoxin and a surfactant. The composition may comprise a crystalline agent.
1. A pharmaceutical composition comprising:
(a) a high purity botulinum neurotoxin or a complex comprising botulinum neurotoxin, wherein the botulinum neurotoxin is of type A, B, C, D, E, F, or G; and
(b) a surfactant;
wherein the composition is a solid or liquid composition and does not comprise albumin or a polysaccharide.
2. The composition of claim 1 , further comprising a sodium chloride.
3. The composition of claim 1 , further comprising a buffer capable of maintaining an aqueous solution at a pH between 5.5 and 7.5.
4. The composition of claim 3 , wherein the buffer is capable of maintaining an aqueous solution at a pH between 5.8 and 7.0.
5. The composition of claim 1 , further comprising a disaccharide.
6. The composition of claim 5 , wherein the disaccharide is sucrose, trehalose, lactose, or mannitol.
7. The composition of claim 1 , comprising a complex comprising botulinum neurotoxin type A.
8. The composition of claim 1 , comprising high purity botulinum neurotoxin type A.
9. The composition of claim 1 , wherein the surfactant is polysorbate 80.