IP Library › Granted Patent US 10,787,439
Granted Patent B2
US 10,787,439 · App. 15/672,574 · Granted Sep 29, 2020

Compounds and methods for activating the apoptotic arm of the unfolded protein response

Inventors: Jennifer E. Golden (Olathe, KS); Jeffrey Aube (Lawrence, KS); Daniel P. Flaherty (Overland Park, KS); Andrew M. Fribley (Brighton, MI); Randal J. Kaufman (San Diego, CA); Thomas D. Y. Chung (Carlsbad, CA); Anthony B. Pinkerton (San Diego, CA); Michael Pablo Hedrick (Carlsbad, CA)
Assignees: UNIVERSITY OF KANSAS; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; WAYNE STATE UNIVERSITY
C07D405/12A61K31/4525A61K31/496A61K31/5377A61K45/06C07C303/36C07D307/71
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Quick Facts
Patent No.
US 10,787,439
App. No.
15/672,574
Granted
Sep 29, 2020
Kind
B2
Abstract

N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

Claims (2)

1. A method of treating an oral squamous cell carcinoma, ovarian cancer or leukemia, in a subject comprising administering to a subject in need of treatment, a pharmaceutical composition comprising the compound:

thereby treating the subject's oral squamous cell carcinoma, ovarian cancer or leukemia.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2017
From: GOLDEN, JENNIFER E.; AUBE, JEFFREY; FLAHERTY, DANIEL P.
To: UNIVERSITY OF KANSAS
Reel/Frame 043331/0447 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2017
From: CHUNG, THOMAS D.Y.; HEDRICK, MICHAEL PABLO; PINKERTON, ANTHONY B.
To: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Reel/Frame 043331/0491 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2017
From: KAUFMAN, RANDAL J.
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Reel/Frame 043331/0535 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2017
From: FRIBLEY, ANDREW M.
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WAYNE STATE UNIVERSITY
Reel/Frame 043331/0603 →
Continuity (3)
Division 14408736
Provisional Application 61662099 · Jun 20, 2012
Related Publication 20170334889A1 · Nov 23, 2017