Anti-microbial peptides and coatings
View Patent ↗Antimicrobial peptides and methods of use are provided.
1. An isolated peptide comprising the amino acid sequence WWWLX 1 X 2 X 3 W (SEQ ID NO: 17), wherein X 1 and X 2 are independently Arg or Lys, and wherein X 3 is selected from the group consisting of Ile, Arg, and Lys.
2. The isolated peptide of claim 1 , wherein X 1 and X 2 are Arg.
3. The isolated peptide of claim 1 , wherein X 3 is Arg.
4. The isolated peptide of claim 1 , wherein said peptide comprises SEQ ID NO NOs: 2, 3, 4, 5, 6, or 14.
5. The isolated peptide of claim 1 , wherein said peptide comprises at least one D-amino acid.
6. The isolated peptide of claim 1 , wherein all of the amino acids are D-amino acids.
7. The isolated peptide of claim 1 , wherein said peptide comprises at least one modification selected from the group consisting of amidation and acetylation.
8. The isolated peptide of claim 1 , wherein said peptide is less than 12 amino acids in length.
9. A composition comprising at least one the peptide of claim 1 and at least one pharmaceutically acceptable carrier.
10. The composition of claim 9 , further comprising at least one antibiotic.
11. A method for inhibiting a bacterial infection in a subject in need thereof, said method comprising administering to said subject the peptide of claim 1 .
12. The method of claim 11 , further comprising the administration of at least one additional antibiotic.
13. The method of claim 11 , wherein said bacterial infection is a staphylococcal infection.
14. The method of claim 11 , wherein said bacterial infection is a methicillin-resistant Staphylococcus aureus (MRSA) infection.
15. The method of claim 11 , wherein said peptide is covalently attached to the surface of a medical device or implant.
16. A medical device or implant comprising the peptide of claim 1 covalently attached to the surface of the medical device or implant.
17. The isolated peptide of claim 1 , wherein said peptide comprises SEQ ID NO: 14.
18. The isolated peptide of claim 1 , wherein said peptide is less than 25 amino acids in length.
19. The isolated peptide of claim 17 , wherein said peptide is less than 25 amino acids in length.
20. The isolated peptide of claim 19 , wherein said peptide is less than 12 amino acids in length.
21. The isolated peptide of claim 19 , wherein said peptide is antibacterial.
22. The isolated peptide of claim 1 , wherein said peptide is antibacterial.
23. The isolated peptide of claim 1 , wherein said peptide is less than 10 amino acids in length.
24. The isolated peptide of claim 1 , consisting of the amino acid sequence WWWLX 1 X 2 X 3 W (SEQ ID NO: 17), wherein X 1 and X 2 are independently Arg or Lys, and wherein X 3 is selected from the group consisting of Ile, Arg, and Lys.