Granted Patent
B2
US 10,435,431 · App. 15/681,983 · Granted Oct 8, 2019
3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
Inventors:
Ravindra B. Upasani (San Jose, CA); Benny C. Askew (Marshfield, MA); Boyd L. Harrison (Princeton Junction, NJ); Francesco G. Salituro (Marlborough, MA); Albert J. Robichaud (Cambridge, MA)
Assignee:
Sage Therapeutics, Inc.
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Abstract
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I) and (III): where R 1 , R 2 , R 3 , R 3′ , R 4 , R 6a , R 6a , R 11a , and R 11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (TBI), stress, and epilepsy.
Claims (3)
1. A process for preparing a compound of Formula 10b:
the process comprising treating a compound of Formula 9b:
with a) trifluoroacetic acid and triethylamine, and b) sodium trifluoroacetate, in refluxing acetone.
Assignments (2)
CHANGE OF NAME
Recorded Aug 18, 2026
From: SAGE THERAPEUTICS, INC.
To: SAGE THERAPEUTICS, LLC
Reel/Frame 075866/0450 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 7, 2022
From: UPASANI, RAVINDRA B.; ASKEW, BENNY C., JR.; HARRISON, BOYD L.; SALITURO, FRANCESCO G.; ROBICHAUD, ALBERT JEAN
To: SAGE THERAPEUTICS, INC.
Reel/Frame 061682/0597 →
Continuity (4)
Continuation
14351449
Provisional Application
61698204
· Sep 7, 2012
Provisional Application
61547291
· Oct 14, 2011