System and method for whole body continuous bed motion parametric pet with flexible scan modes

1. A method of processing and reconstructing dynamic positron emission tomography (PET) sinogram data, comprising:

acquiring PET sinogram data using continuous bed motion having a varying velocity;

recording a plurality of position-time coordinate pairs while acquiring the PET sinogram data;

determining respective slice acquisition times of each of a plurality of slices of an image, based on the plurality of position-time coordinate pairs;

calculating a respective value of a blood input function and an integral of the blood input function for each respective slice acquisition time; and

reconstructing respective parametric images for each respective slice in the plurality of slices based on the respective slice acquisition times, the respective value of the blood input function, and the integral of the blood input function of each of the plurality of slices in the image,

wherein determining the respective slice acquisition time for each slice includes determining a reference time when an average tracer activity of the slice occurs, and

wherein the respective value of the blood input function corresponds to the reference time when the average tracer activity occurs for each respective slice.

2. The method of processing and reconstructing dynamic PET sinogram data according to claim 1 , further comprising:

injecting radioactive tracer into a human body, and then

acquiring PET sinogram data over a heart region using single bed mode, between the injecting and using continuous bed motion.

3. The method of processing and reconstructing dynamic PET sinogram data according to claim 1 , further comprising obtaining a blood input function from a single bed acquisition and the sinogram data acquired using continuous bed motion, wherein the blood input function from the single bed acquisition and the sinogram data is used to calculate the respective value of the blood input function and the integral of the blood input function for each respective slice acquisition time.

4. The method of processing and reconstructing dynamic PET sinogram data according to claim 1 , wherein the parametric images include a metabolism rate image and a distribution volume image.

5. The method of processing and reconstructing dynamic PET sinogram data according to claim 1 , wherein time coordinates of successive ones of the position-time coordinate pairs are separated from each other by a constant time interval.

6. The method of processing and reconstructing dynamic PET sinogram data according to claim 5 , wherein position coordinates of the position-time coordinate pairs are separated from each other by varying position intervals.

7. The method of processing and reconstructing dynamic PET sinogram data according to claim 1 , wherein the continuous bed motion having the varying velocity includes same-direction, multi-pass motion.

8. The method of processing and reconstructing dynamic PET sinogram data according to claim 1 , wherein the continuous bed motion having the varying velocity includes bidirectional motion.

9. The method of processing and reconstructing dynamic PET sinogram data according to claim 1 , wherein the continuous bed motion having the varying velocity includes a combination of single-direction motion over a first portion of an axial range of bed motion and bidirectional motion over a second portion of the axial range of bed motion.

10. The method of processing and reconstructing dynamic PET sinogram data according to claim 1 , wherein reconstructing the respective parametric images includes direct reconstruction of parametric images from a PET sinogram dataset having two or more dynamic frames.

11. A system for processing and reconstructing dynamic positron emission tomography (PET) sinogram data, comprising:

a processor capable of executing instructions; and

a non-transitory, machine-readable storage medium encoded with program code and coupled to the processor, the storage medium comprising:

code for controlling a PET scanner to acquire PET sinogram data using continuous bed motion having a varying velocity;

code for recording a plurality of position-time coordinate pairs while the PET scanner acquires the PET sinogram data;

code for determining respective acquisition times of each of a plurality of slices of an image, based on the plurality of position-time coordinates, wherein the code for determining the respective acquisition time for each slice includes code for determining a reference time when an average tracer activity of the slice occurs;

code for calculating a respective value of a blood input function and an integral of the blood input function for each respective slice acquisition time; and

code for reconstructing respective parametric images for each respective slice in the plurality of slices based on the respective slice acquisition times, the respective value of the blood input function, and the integral of the blood input function of each of the plurality of slices in the image,

wherein determining the respective slice acquisition time for each slice includes determining a reference time when an average tracer activity of the slice occurs, and

wherein the respective value of the blood input function corresponds to the reference time when an average tracer activity occurs for each respective slice.

12. The system for processing and reconstructing dynamic PET sinogram data according to claim 11 , wherein the code for controlling configures the processor so that time coordinates of successive ones of the position-time coordinate pairs are separated from each other by a constant time interval.

13. The system for processing and reconstructing dynamic PET sinogram data according to claim 12 , wherein the code for controlling configures the processor so that position coordinates of the position-time coordinate pairs are separated from each other by a varying position intervals.

14. A non-transitory, machine-readable storage medium encoded with program code for processing and reconstructing dynamic positron emission tomography (PET) sinogram data, comprising:

code for controlling a PET scanner to acquire PET sinogram data using continuous bed motion having a varying velocity;

code for recording a plurality of position-time coordinate pairs while the PET scanner acquires the PET sinogram data;

code for determining respective acquisition times of each of a plurality of slices of an image, based on the plurality of position-time coordinates, wherein the code for determining the respective acquisition time for each slice includes code for determining a reference time when an average tracer activity of the slice occurs;

code for calculating a respective value of a blood input function and an integral of the blood input function for each respective slice acquisition time; and

code for reconstructing respective parametric images for each respective slice in the plurality of slices based on the respective acquisition times, the respective value of the blood input function, and the integral of the blood input function of each of the plurality of slices in the image,

wherein determining the respective slice acquisition time for each slice includes determining a reference time when an average tracer activity of the slice occurs, and

wherein the respective value of the blood input function corresponds to the reference time when the average tracer activity occurs for each respective slice.

15. The non-transitory, machine-readable storage medium encoded with program code for processing and reconstructing dynamic PET sinogram data according to claim 14 , wherein the code for control is for configuring the processor so that position coordinates of the position-time coordinate pairs are separated from each other by a varying position intervals.