Methods and materials for treating cancer
This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an SCD1 polypeptide to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)) or to increase the efficacy of a renal cell carcinoma treatment are provided. In addition, this document provides methods and materials for using elevated SCD1 expression levels in diseased tissues as an indication that an SCD1 inhibitor can be used as an appropriate therapeutic to ameliorate the disease.
1. A method for reducing the number of cancer cells within a mammal in need thereof, wherein the method comprises administering, to the mammal, an inhibitor of an SCD1polypeptide under conditions wherein the number of viable cancer cells present within the mammal is reduced, wherein the cancer cells are selected from the group consisting of thyroid cancer cells, melanoma cells, ovarian cancer cells, pancreatic cancer cells, renal cancer cells, and bladder cancer cells.
2. The method of claim 1 , wherein the cancer cells are selected from the group consisting of: anaplastic thyroid carcinoma cells, malignant melanoma cells, epithelial ovarian tumor cells, pancreatic ductal adenocarcinoma cells, clear cell renal cell carcinoma, and human urothelial bladder cancer cells.
3. The method of claim 2 , wherein the cancer cells are anaplastic thyroid carcinoma cells.
4. The method of claim 2 , wherein the cancer cells are malignant melanoma cells.
5. The method of claim 2 , wherein the cancer cells are epithelial ovarian tumor cells.
6. The method of claim 2 , wherein the cancer cells are pancreatic ductal adenocarcinoma cells.
7. The method of claim 2 , wherein the cancer cells are clear cell renal cell carcinoma cells.
8. The method of claim 2 , wherein the cancer cells are human urothelial bladder cancer cells.
9. The method of claim 2 , wherein the mammal is a human.
10. The method of claim 2 , wherein the administration is an intratumoral, oral, intraperitoneal, intramuscular, or intravenous administration.
11. The method of claim 2 , wherein the inhibitor is A939572, MK-8245, CVT-11127, MF-152, MF-438, or HYR-061.
12. A method for reducing the number of cancer cells within a mammal in need thereof, wherein the method comprises administering, to the mammal, a composition under conditions wherein the number of cancer cells present within the mammal is reduced, wherein the composition comprises the ability to reduce SCD1mRNA expression or SCD1 polypeptide expression, wherein the cancer cells are selected from the group consisting of thyroid cancer cells, melanoma cells, ovarian cancer cells, pancreatic cancer cells, renal cancer cells, and bladder cancer cells.
13. The method of claim 12 , wherein the cancer cells are selected from the group consisting of: anaplastic thyroid carcinoma cells, malignant melanoma cells, epithelial ovarian tumor cells, pancreatic ductal adenocarcinoma cells, clear cell renal cell carcinoma, and human urothelial bladder cancer cells.
14. The method of claim 13 , wherein the cancer cells are anaplastic thyroid carcinoma cells.
15. The method of claim 13 , wherein the cancer cells are malignant melanoma cells.
16. The method of claim 13 , wherein the cancer cells are epithelial ovarian tumor cells.
17. The method of claim 13 , wherein the cancer cells are pancreatic ductal adenocarcinoma cells.
18. The method of claim 13 , wherein the cancer cells are clear cell renal cell carcinoma cells.
19. The method of claim 13 , wherein the cancer cells are human urothelial bladder cancer cells.
20. The method of claim 12 , wherein the mammal is a human.
21. The method of claim 12 , wherein the administration is an intratumoral, oral, intraperitoneal, intramuscular, or intravenous administration.
22. The method of claim 12 , wherein the composition comprises a nucleic acid construct having the ability to express a shRNA directed against SCD1nucleic acid.