IP Library › Granted Patent US 10,081,619
Granted Patent B2
US 10,081,619 · App. 15/699,857 · Granted Sep 25, 2018

Biaryl inhibitors of bruton's tyrosine kinase

Inventors: Brian T. Hopkins (Newton, MA); Bin Ma (Arlington, MA); Timothy Raymond Chan (Newton, MA); Lihong Sun (Lexington, MA); Lei Zhang (Westford, MA); Gnanasambandam Kumaravel (Westford, MA); Joseph P. Lyssikatos (Cambridge, MA); Kevin Koch (Cambridge, MA); Hua Miao (Newton, MA)
Assignee: BIOGEN MA INC.
C07D403/12C07D401/14C07D409/14C07D413/14C07D417/12C07D417/14C07D487/04C07D495/04C07D513/04
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Quick Facts
Patent No.
US 10,081,619
App. No.
15/699,857
Granted
Sep 25, 2018
Kind
B2
Abstract

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Claims (7)

1. A compound represented by the following formula:

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is represented by the following formula:

or a pharmaceutically acceptable salt thereof.

3. A compound represented by the following formula:

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 3 , wherein the compound is represented by the following formula:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2017
From: HOPKINS, BRIAN T.; MA, BIN; CHAN, TIMOTHY RAYMOND; SUN, LIHONG; ZHANG, LEI; KUMARAVEL, GNANASAMBANDAM; LYSSIKATOS, JOSEPH P.; KOCH, KEVIN; MIAO, HUA
To: BIOGEN MA INC.
Reel/Frame 044452/0212 →
Continuity (3)
Continuation 15103749
Provisional Application 61914886 · Dec 11, 2013
Related Publication 20180093973A1 · Apr 5, 2018