Fluorescent probes for detecting hydrogen polysulfides
Reactive sulfur species have been recognized as an important regulator in redox biology, wherein the reactive sulfur species have been shown to be active in tumor suppressors, ion channels, and transcription factors. The disclosed invention is a novel composition of matter that allows for the detection of H 2 S and H 2 S n species in living cells. These novel compositions represent significant progress in the field of chemical, H 2 S and H 2 S n probes as they have both been successfully applied in the visualization sulfur species in living systems.
1. A compound of formula (I):
or any acceptable salt thereof, wherein
R═—SH, —OH, —SO 2 H, —S(CO)R 1 ;
R 1 is selected from the group consisting of substituted alkyl, unsubstituted alkyl, substituted aryl and unsubstituted aryl.
2. The compound of claim 1 , wherein R is S(CO)R 1 wherein R 1 is substituted alkyl.
3. The compound of claim 1 , wherein R is S(CO)R 1 wherein R 1 is substituted aryl.
4. The compound of claim 1 , and R is SH.