Prodrugs of fumarates and their use in treating various diseases
The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
1. A pharmaceutical composition comprising a compound of Formula (Ia), or a pharmaceutically acceptable salt thereof:
wherein:
R 1 is unsubstituted C 1 -C 6 alkyl;
L a is unsubstituted C 1 -C 6 alkyl linker; and
R 2 is H, unsubstituted C 1 -C 6 alkyl, unsubstituted C 2 -C 6 alkenyl, or unsubstituted C 2 -C 6 alkynyl; and
a pharmaceutically acceptable carrier.
2. The composition of claim 1 , wherein R 1 is methyl.
3. The composition of claim 1 , wherein L a is an unsubstituted C 1 -C 3 alkyl.
4. The composition of claim 3 , wherein L a is an unsubstituted C 2 alkyl.
5. The composition of claim 1 , wherein R 2 is an unsubstituted C 1 -C 6 alkyl, unsubstituted C 2 -C 6 alkenyl, or unsubstituted C 2 -C 6 alkynyl.
6. The composition of claim 5 , wherein R 2 is an unsubstituted C 1 -C 6 alkyl.
7. The composition of claim 6 , wherein R 2 is an unsubstituted C 1 -C 3 alkyl.
8. The composition of claim 7 , wherein R 2 is an unsubstituted C 1 -C 2 alkyl.
9. The composition of claim 8 , wherein R 2 is methyl.
10. The composition of claim 1 , wherein the compound of Formula (Ia) has the structure:
or a pharmaceutically acceptable salt thereof.