IP Library › Granted Patent US 10,111,882
Granted Patent B2
US 10,111,882 · App. 15/705,139 · Granted Oct 30, 2018

SYK inhibitors

Inventors: Esteban M. Abella (Emerald Hills, CA); Julie A. Di Paolo (San Francisco, CA); Kathleen S. Keegan (Bainbridge Island, WA); Antonio Mario Querido Marcondes (Millbrae, CA); Yang Pan (San Mateo, CA); Arati V. Rao (Palo Alto, CA)
Assignee: GILEAD SCIENCES, INC.
A61K31/5377A61K31/4985
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Quick Facts
Patent No.
US 10,111,882
App. No.
15/705,139
Granted
Oct 30, 2018
Kind
B2
Abstract

The application provides methods of treating or reducing thrombocytopenia, leukopenia, anemia, or neutropenia in a patient in need thereof, comprising the step of administering an effective amount of a compound selected from Compounds 1-6, disclosed herein.

Claims (12)

1. A method of treating or reducing aplastic anemia in a patient in need thereof, comprising administering to the patient an effective amount of a compound selected from:

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein compound is

or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 , wherein compound is

or a pharmaceutically acceptable salt thereof.

4. The method of claim 1 , wherein compound is

or a pharmaceutically acceptable salt thereof.

5. The method of claim 1 , wherein compound is

or a pharmaceutically acceptable salt thereof.

6. The method of claim 1 , wherein compound is

or a pharmaceutically acceptable salt thereof.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 15, 2026
From: KRONOS BIO, INC.
To: IGNOTA LABS LIMITED
Reel/Frame 075623/0675 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2020
From: GILEAD SCIENCES, INC.
To: KRONOS BIO, INC.
Reel/Frame 053797/0166 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY PREVIOUSLY RECORDED AT REEL: 043606 FRAME: 0984. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 21, 2018
From: KEEGAN, KATHLEEN S.
To: GILEAD SCIENCES, INC.
Reel/Frame 047128/0536 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 15, 2017
From: ABELLA, ESTEBAN M.; DI PAOLO, JULIE A.; KEEGHAN, KATHLEEN S.; MARCONDES, ANTONIO MARIO QUERIDO; PAN, YANG; RAO, ARATI V.
To: GILEAD SCIENCES, INC.
Reel/Frame 043606/0984 →
Continuity (4)
Provisional Application 62429209 · Dec 2, 2016
Provisional Application 62416047 · Nov 1, 2016
Provisional Application 62394573 · Sep 14, 2016
Related Publication 20180071302A1 · Mar 15, 2018
Cited By (2)
US 12,263,163 US 12,268,690