IP Library Granted Patent US 10,398,670
Granted Patent B2
US 10,398,670 · App. 15/706,323 · Granted Sep 3, 2019

Oral microbiota promotion for oral and/or sinus infections

Inventor: Shunsheng Han (Los Alamos, NM)
Assignee: Knoze Jr. Corporation
A61K31/198A23L33/135A61K9/0053A61K9/0056A61K31/702A61K31/7016A61K31/719A61K31/733A61K35/644A61K36/185A61K36/54A61K36/736A61K36/898A61P31/00B08B3/10A23V2002/00
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Quick Facts
Patent No.
US 10,398,670
App. No.
15/706,323
Granted
Sep 3, 2019
Kind
B2
Abstract

A method of promoting a desired oral microbiota to treat an oral and/or sinus infection condition in a subject in need of such treatment including providing a preformulated prebiotic edible composition including an amino acid containing ingredient comprising individual molecules of L-arginine; substantially removing a biofilm from surfaces within an oral cavity by heating the inside of the oral cavity to a temperature of about 100 deg F. to about 130 deg F.; wherein following removal of the biofilm, the composition is provided contained and at least partially dissolved within an oral cavity of the subject for a period of at least from about 30 seconds to about an hour on a daily basis of at least two consecutive days to promote an increased concentration of selected oral microbiota, the selected microbiota comprising Veillonella and Streptococcus , thereby treating the oral and/or sinus infection condition.

Claims (29)

1. A method of promoting a desired oral microbiota to treat an oral and/or sinus infection condition in a subject in need of such treatment comprising:

providing a preformulated prebiotic edible composition comprising an amino acid containing ingredient comprising separate individual molecules of L-arginine;

substantially removing a biofilm from surfaces within an oral cavity comprising heating the inside of the oral cavity to a temperature of about 105 deg F. to about 130 deg F.;

wherein following removal of the biofilm, the composition is contained and at least partially dissolved within an oral cavity of the subject for a period of at least from about 30 seconds to about an hour on a daily basis of at least two consecutive days in an effective amount to selectively promote an increased concentration of selected oral microbiota, the selectively promoted microbiota comprising Veillonella and Streptococcus , thereby treating the oral and/or sinus infection condition.

2. The method of claim 1 , wherein the oral and/or sinus infection condition comprises one or more of gingivitis, periodontitis, tonsillitis, rhinosinusitis, pharyngitis, and laryngitis.

3. The method of claim 1 , wherein the composition is provided in a carrier.

4. The method of claim 3 , wherein the carrier comprises a solid, powder or liquid.

5. The method of claim 3 , wherein the carrier comprises one or more of a chewable tablet, an edible capsule, and a hygienic paste, and an edible food.

6. The method of claim 3 , wherein the carrier is supported on a bioadhesive strip configured for adhesion within an oral cavity.

7. The method of claim 1 , wherein the composition is provided within the oral cavity from a period of from about 2 consecutive days to about 60 consecutive days.

8. The method of claim 1 , wherein heating the inside of the oral cavity comprises periodic oral rinsing with a heated liquid, each rinsing for about 10 seconds to about 1 minute over a period of from about 5 to about 15 minutes.

9. The method of claim 8 , wherein removal of the biofilm comprises at least one of brushing and rubbing the oral cavity with the heated liquid.

10. The method of claim 1 , wherein the at least one amino acid further comprises at least one of L-cysteine, DL-aspartic acid, L-glutamic acid, L-serine, and L-tyrosine.

11. The method of claim 1 , wherein the amino acid containing ingredient is present in the composition at a weight percent level of from about 0.1 wt. % to about 99.9 wt. %.

12. The method of claim 1 , wherein the amino acid containing ingredient is present in the composition at a weight percent level of from about 5.0 wt. % to about 95.0 wt.

13. The method of claim 1 , wherein the composition further comprises a sugar containing ingredient, the sugar comprising one or more of monosaccharides, disaccharides, oligosaccharides, and polysaccharides.

14. The method of claim 13 , wherein the sugar comprises one or more of mannose, lactose, malibiose, maltose, cellobiose, trehalose, raffinose, stachyose, and verbascose.

15. The method of claim 13 , wherein the composition further comprises polysaccharide polymers.

16. The method of claim 15 , wherein the polysaccharide polymers comprise one or more of pullulan and inulin.

17. The method of claim 13 , wherein the sugar ingredient comprises jujube fruit extract comprising one or more of rhamnose, xylitol, arabitol, fructose, glucose, inositol, sucrose, and maltose.

18. The method of claim 13 , wherein the sugar is present in the composition at a weight percent level of from about 0.1 wt. % to about 95 wt. %.

19. The method of claim 13 , wherein the sugar is present in the composition at a weight percent level of from about 0.5 wt. % to about 95 wt. %.

20. The method of claim 13 , wherein the sugar is present in the composition at a weight percent level of from about 5.0 wt. % to about 95.0 wt. %.

21. The method of claim 1 , wherein at least one of the composition and oral cavity further comprises live bacteria comprising a lactic acid producing bacterium and a lactate fermenting bacterium at a level of from about 1000 to about 1,000,000,000 living cells.

22. The method of claim 1 , wherein Streptococcus includes one or more of S. salivarius and S. thermophilus and wherein Veillonella comprises one or more of V. Dispar and V. Parvula.

23. A method of promoting a desired oral microbiota to treat an oral and/or sinus infection condition in a subject in need of such treatment comprising:

providing a preformulated prebiotic edible composition comprising an amino acid containing ingredient comprising separate individual molecules of L-arginine;

substantially removing a biofilm from surfaces within an oral cavity comprising heating the inside of the oral cavity to a temperature of about 100 deg F. to about 130 deg F. over a period of from about 5 to about 15 minutes;

wherein following removal of the biofilm, the composition is contained and at least partially dissolved within an oral cavity of the subject for a period of at least from about 30 seconds to about an hour on a daily basis of at least two consecutive days in an effective amount to selectively promote an increased concentration of selected oral microbiota, the selectively promoted microbiota comprising Veillonella and Streptococcus , thereby treating the oral and/or sinus infection condition.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 15, 2017
From: HAN, SHUNSHENG, MR.
To: KNOZE JR. CORPORATION
Reel/Frame 043867/0930 →
Continuity (2)
Continuation In Part 15495188 · Apr 24, 2017
Related Publication 20180303782A1 · Oct 25, 2018