Anaerobic blood storage containers
A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.
1. A blood storage device 20 for storing oxygen depleted blood comprising:
an outer receptacle 201 substantially impermeable to oxygen;
a collapsible blood container 202 ; and
at least one inlet/outlet 30 that is substantially impermeable to oxygen passing through said outer receptacle 201 and that is in fluid communication with said collapsible container 202 ; and
an oxygen sorbent 207 situated within said outer receptacle 201 ,
wherein said at least one inlet/outlet 30 comprises a unitary tube that is substantially impermeable to oxygen comprising tubing 304 , bond 302 , and tubing 205 , wherein said unitary tube is a barrier traversing tube 305 comprising an outer layer 308 , an inner layer 306 , and an oxygen barrier layer 307 .
2. The blood storage device of claim 1 , wherein said sorbent 207 situated within said outer receptacle 201 further comprises a carbon dioxide sorbent.
3. The blood storage device of claim 1 , wherein said at least one oxygen barrier layer of barrier traversing tube 305 is selected from the group consisting of ethylene-vinyl acetate (EVA), ethyl vinyl alcohol (EVOH), poly(ethylene-vinyl) acetate (PEVA), polypropylene (PP), polyacrylonitrile (PAN), polyvinylidene chloride (PVDC), polyvinylidene fluoride (PVDF), polyurethane (PU), polyethylene terephthalate (PET), polyethylene napthalate (PEN), and polyamide.
4. The blood storage device of claim 1 , wherein said tubing 304 is a barrier traversing tube having an oxygen barrier layer 307 selected from the group consisting of ethylene-vinyl acetate (EVA), ethyl vinyl alcohol (EVOH), poly(ethylene-vinyl) acetate (PEVA), polypropylene (PP), polyacrylonitrile (PAN), polyvinylidene chloride (PVDC), polyvinylidene fluoride (PVDF), polyurethane (PU), polyethylene terephthalate (PET), polyethylene napthalate (PEN), and polyamide.
5. The blood storage device of claim 1 , wherein said tubing 205 is selected from the group consisting of ethylene-vinyl acetate (EVA), ethyl vinyl alcohol (EVOH), poly(ethylene-vinyl) acetate (PEVA), polypropylene (PP), polyacrylonitrile (PAN), polyvinylidene chloride (PVDC), polyurethane (PU), polyethylene terephthalate (PET), polyethylene napthalate (PEN), and polyamide.
6. The blood storage device of claim 1 , wherein said tubing 205 comprises polyvinyl chloride (PVC) having a Barrer value of less than 3 Barrer.
7. The blood storage device of claim 1 , wherein said tubing 304 comprises polyvinyl chloride (PVC) having a Barrer value of less than 3 Barrer.
8. The blood storage device of claim 1 , wherein said collapsible blood container 202 has a moisture vapor transmission rate (MVTR) of 10 g/m 2 /24 hrs or less when tested at a temperature of 23±2° C.
9. The blood storage device of claim 1 , further comprising a spacer 213 selected from the group consisting of a mesh, a molded mat, a woven mat, a non-woven mat, an open cell foam, a strand veil, and a strand mat.
10. A blood storage device 20 for storing oxygen depleted blood comprising:
outer receptacle 201 substantially impermeable to oxygen;
a spacer 213 ;
an oxygen sorbent 207 situated within said outer receptacle 201 ,
a collapsible blood container 202 ; at least one inlet/outlet 30 that is substantially impermeable to oxygen passing through said outer receptacle 201 and that is in fluid communication with said collapsible container 202 .
11. The blood storage device of claim 10 , wherein said sorbent 207 situated within said outer receptacle 201 further comprises a carbon dioxide sorbent.
12. The blood storage device of claim 10 , wherein said spacer 213 is selected from the group consisting of a mesh, a molded mat, a woven mat, a non-woven mat, an open cell foam, a strand veil, and a strand mat.
13. The blood storage device of claim 10 , wherein said spacer 213 is integrated into at least one of said inner collapsible blood container 202 or outer receptacle 201 as a rib, dimple, or other raised feature that maintains a separation between said outer receptacle 201 and said inner collapsible blood container 202 .
14. The blood storage device of claim 10 , wherein said outer receptacle 201 that is substantially impermeable to oxygen consists of a heat sealable polyethylene (PE) inner layer, an alumina barrier middle later, and a polyethylene terephthalate (PET) layer.
15. The blood storage device of claim 10 , wherein said outer receptacle that is substantially impermeable to oxygen comprises a polyethylene terephthalate (PET).
16. The blood storage device of claim 10 , wherein said PET further comprises a barrier coating of silica or alumina.
17. The blood storage device of claim 10 , wherein said outer receptacle further comprises a polyolefin inner layer.
18. The blood storage device of claim 10 , wherein said collapsible blood container 202 comprises PVC with DEHP.
19. The blood storage device of claim 10 , wherein said collapsible blood container 202 has a moisture vapor transmission rate (MVTR) of 10 g/m 2 /24 hrs or less when tested at a temperature of 23±2° C.
20. The blood storage device of claim 10 , wherein said at least one inlet/outlet 30 comprises a unitary tube that is substantially impermeable to oxygen comprising tubing 304 , bond 302 , and tubing 205 , wherein said unitary tube is a barrier traversing tube 305 comprising an outer layer 308 , an inner layer 306 , and an oxygen barrier layer 307 .