IP Library › Granted Patent US 10,781,268
Granted Patent B2
US 10,781,268 · App. 15/711,181 · Granted Sep 22, 2020

Method for decreasing immunogenicity

Inventors: David Urech (Jona, CH); Leonardo Borras (Schlieren, CH)
Assignee: Novartis AG
C07K16/42C07K16/241C07K2317/24C07K2317/34C07K2317/622C07K2317/76
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Quick Facts
Patent No.
US 10,781,268
App. No.
15/711,181
Granted
Sep 22, 2020
Kind
B2
Abstract

A method for decreasing the immunogenicity of antibody variable domains is disclosed.

Claims (5)

1. An antibody variable domain comprising a variable light chain comprising serine (S) at position 99 (Aho numbering), and a variable heavy chain comprising Serine (S) at heavy chain amino acid position 12, Threonine (T) at heavy chain amino acid position 103, and Threonine (T) at heavy chain amino acid position 144 (AHo numbering).

2. The antibody variable domain of claim 1 , being an scFv or an Fv fragment.

3. The antibody variable domain of claim 1 , being an scFv.

4. The antibody variable domain of claim 1 , wherein the Serine (S) at position 99 of the variable light chain is introduced by substitution.

5. A pharmaceutical composition comprising the antibody variable domain of claim 1 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2020
From: ESBATECH A NOVARTIS COMPANY LLC
To: NOVARTIS AG
Reel/Frame 053534/0309 →
Continuity (4)
Division 14308936 · Jun 19, 2014
Division 12973968 · Dec 21, 2010
Provisional Application 61289446 · Dec 23, 2009
Related Publication 20180016350A1 · Jan 18, 2018