COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR USE IN VASCULAR INTERVENTION
This invention relates to collagen-binding synthetic peptidoglycans. More particularly, this invention relates to collagen-binding synthetic peptidoglycans for use in vascular intervention procedures. The invention also relates to kits comprising such collagen-binding synthetic peptidoglycans and catheters or stents.
1 . A peptidoglycan comprising a glycan and from 15 to 25 synthetic peptides of up to 40 amino acids comprising the amino acid sequence GELYKSILY (SEQ ID NO: 25).
2 . The peptidoglycan of claim 1 , wherein the glycan is dermatan sulfate or chondroitin sulfate.
3 . The peptidoglycan of claim 1 , wherein the peptide is a synthetic peptide of up to 40 amino acids comprising the amino acid sequence RRANAALKAGELYKSILY (SEQ ID NO: 17).
4 . The peptidoglycan of claim 1 , wherein the peptidoglycan comprises about 20 synthetic peptides.
5 . The peptidoglycan of claim 1 , wherein the peptidoglycan comprises about 18 synthetic peptides.
6 . The peptidoglycan of claim 1 , wherein the peptide is bonded to the glycan via a linker.
7 . A composition comprising the peptidoglycan of claim 1 and one or more additional agent.
8 . The composition of claim 7 , wherein each one or more additional agent is independently selected from the group consisting of a pH buffering agent, ionic strength modifying agent, viscosity modulating agent, and solubility-enhancing agent.