Processes for the convergent synthesis of calicheamicin derivatives
This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
1. A compound selected from:
butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutoxy]phenyl]ethylidene]hydrazide; and
butanoic acid,3-mercapto-3-methyl-,2-[(E)-1[4-(4-hydroxy-4-oxobutoxy)phenyl]ethylidene]hydrazide.
2. A sodium salt of butanoic acid,3-mercapto-3 -methyl -,2-[(E)-1-[4-[4-[(2,5 -dioxo-1-pyrrolidinyl)oxy] -4-oxobutoxy]phenyl]ethylidene]hydrazide.
3. A sodium salt of butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-(4-hydroxy-4-oxobutoxy)phenyl]ethylidene]hydrazide.
4. The compound of claim 1 , wherein the compound is butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutoxy]phenyl]ethylidene]hydrazide.
5. The compound of claim 1 , wherein the compound is butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-(4-hydroxy-4-oxobutoxy)phenyl]ethylidene]hydrazide.