Methods of altering programmed cell death and extending cell life
In one aspect, a method of altering programmed cell death includes administering to an individual in need thereof a therapeutically effective amount of isomyosmine or a pharmaceutically acceptable salt thereof. In other aspects, isomyosmine is administered to treat a wound, hemochromatosis, traumatic brain injury, or disorders associated with chronic oxidative stress. In other aspects, isomyosmine is administered to increase blood oxygen saturation levels.
1. A method of altering programmed cell death in an individual comprising administering to the individual a pharmaceutical composition containing a therapeutically effective amount of isomyosmine or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein altering programmed cell death is effective to extend lifespan of beta cells in the individual.
3. The method of claim 1 , wherein altering programmed cell death is effective to extend cell longevity in the individual.
4. The method of claim 1 , wherein altering programmed cell death is effective to maintain telomerase at levels sufficient to lengthen telomeres.
5. The method of claim 1 , wherein the therapeutically effective amount is from about 0.001 to about 100 mg/kg/day.
6. The method of claim 1 , wherein the therapeutically effective amount is from about 0.01 to about 75 mg/kg/day.
7. The method of claim 1 , wherein the therapeutically effective amount is from about 0.1 to about 50 mg/kg/day.
8. The method of claim 1 , wherein the therapeutically effective amount is from about 1 to about 25 mg/kg/day.
9. The method of claim 1 , wherein the therapeutically effective amount is from about 5 to about 15 mg/kg/day.
10. A method of treating frailty comprising administering to an individual in need thereof a pharmaceutical composition containing a therapeutically effective amount of isomyosmine or a pharmaceutically acceptable salt thereof.
11. The method of claim 10 , wherein the therapeutically effective amount is from about 0.001 to about 100 mg/kg/day.
12. The method of claim 10 , wherein the therapeutically effective amount is from about 0.01 to about 75 mg/kg/day.
13. The method of claim 10 , wherein the therapeutically effective amount is from about 0.1 to about 50 mg/kg/day.
14. The method of claim 10 , wherein the therapeutically effective amount is from about 1 to about 25 mg/kg/day.
15. The method of claim 10 , wherein the therapeutically effective amount is from about 5 to about 15 mg/kg/day.