Compositions and methods for treatment of skin disorders

1. A method of treating a skin disorder or condition comprising applying to the skin of a subject in need thereof, or adding to a composition that is applied to the skin of a subject in need thereof, a pharmaceutical composition comprising:

a) a therapeutically effective amount of a health-associated Propionibacterium acnes microbe, wherein the health-associated Propionibacterium acnes microbe is characterized by the following:

i) it comprises at least one of a gene encoding a deoxyribose operon repressor and a gene encoding a type II lipase;

ii) it does not comprise a pIMPLE plasmid;

iii) it comprises at least one gene encoding an ATP binding cassette transporter;

iv) it lacks a gene encoding a DNA binding response regulator and a gene encoding a phosphoglycerate kinase; and

v) it lacks a gene encoding a CAMP2 protein; and

b) a biological stabilizer.

2. The method of claim 1 , wherein the skin disorder or condition is acne.

3. The method of claim 1 , wherein the pharmaceutical composition is in a form selected from a lotion, foam, gel, emollient, cream, emulsion, and ointment.

4. The method of claim 1 , wherein the biological stabilizer comprises a cryopreservative.

5. The method of claim 4 , wherein the cryopreservative comprises glycerol.

6. The method of claim 1 , wherein the pharmaceutical composition comprises about 5% to about 40% glycerol.

7. The method of claim 1 , wherein the pharmaceutical composition is formulated to provide a skin pH between about 4.5 and about 6.5.

8. The method of claim 1 , wherein the pharmaceutical composition comprises Vitamin C.

9. The method of claim 1 , wherein the pharmaceutical composition is freeze dried or lyophilized.

10. The method of claim 1 , wherein the biological stabilizer comprises an oil.

11. The method of claim 1 , wherein the pharmaceutical composition is vacuum sealed.

12. The method of claim 1 , wherein the health-associated Propionibacterium acnes microbe comprises a gene encoding type II lipase.

13. The method of claim 1 , wherein a Cas5 protein is present in the health-associated Propionibacterium acnes microbe.

14. The method of claim 1 , wherein the health-associated Propionibacterium acnes microbe does not express transposase 2.

15. The method of claim 1 , wherein the health-associated Propionibacterium acnes microbe is ribotype RT 1.

16. The method of claim 1 , wherein the health-associated Propionibacterium acnes microbe is ribotype RT 2.

17. The method of claim 1 , wherein the health-associated Propionibacterium acnes microbe is not ribotype RT6.

18. The method of claim 1 , wherein the health-associated Propionibacterium acnes microbe is a strain selected from the group consisting of HP3A11, HP3B4, HP4G1, and HP5G4.

19. The method of claim 1 , wherein the health-associated Propionibacterium acnes microbe is strain HP4G1.