Carboxylic acid compound, method for preparation thereof, and use thereof
The present invention relates to the technical field of medicine, and specifically relates to the carboxylic acid compound represented by the chemical formula I or chemical formula II, and a pharmaceutically acceptable salt, a prodrug, and a solvate thereof, and a method for preparation thereof, as well as a pharmaceutical composition containing the described substances, and a use thereof.
1. A compound selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
11. A pharmaceutical composition comprising the carboxylic acid compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
12. A method of treating gout in a human, comprising administering to the human an effective amount of a compound selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
13. The method of claim 12 , comprising administering to the human an effective amount of compound
or a pharmaceutically acceptable salt thereof.
14. The method of claim 12 , comprising administering to the human an effective amount of compound
or a pharmaceutically acceptable salt thereof.
15. The method of claim 12 , comprising administering to the human an effective amount of compound
or a pharmaceutically acceptable salt thereof.
16. The method of claim 12 , comprising administering to the human an effective amount of compound
or a pharmaceutically acceptable salt thereof.
17. The method of claim 12 , comprising administering to the human an effective amount of compound
or a pharmaceutically acceptable salt thereof.
18. The method of claim 12 , comprising administering to the human an effective amount of compound
or a pharmaceutically acceptable salt thereof.
19. The method of claim 12 , comprising administering to the human an effective amount of compound
or a pharmaceutically acceptable salt thereof.
20. The method of claim 12 , comprising administering to the human an effective amount of compound
or a pharmaceutically acceptable salt thereof.
21. The method of claim 12 , comprising administering to the human an effective amount of compound
or a pharmaceutically acceptable salt thereof.
22. A method of reducing the blood uric acid level in a human, comprising administering to the human an effective amount of a compound selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
23. A method of treating hyperuricemia in a human, comprising administering to the human an effective amount of a compound selected from the group consisting of
or a pharmaceutically acceptable salt thereof.