Granted Patent
B2
US 10,234,455 · App. 15/729,034 · Granted Mar 19, 2019
Regulatory brain specific ctyoplasmic RNAs (BC RNAs) and methods of use thereof in diagnosis and treatment of neuropsychiatric lupus
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Abstract
Compositions and methods for diagnosing an increased risk of NPSLE are provided.
Claims (2)
1. A method of inhibiting the binding of an anti-BC RNA (regulatory brain specific cytoplasmic RNA) autoantibody or fragment thereof to BC RNA, said method comprising contacting the anti-BC RNA autoantibody or fragment thereof with a composition comprising an anti-autoimmune reagent that specifically binds to an anti-BC RNA autoantibody or fragment thereof, wherein the anti-autoimmune reagent is one or more GA motifs of BC RNA.
2. The method of claim 1 , wherein the anti-BC RNA autoantibody or fragment thereof is associated with the pathology of neuropsychiatric lupus.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Jan 24, 2024
From: STATE UNIVERSITY OF NEW YORK
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 066369/0483 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 13, 2018
From: TIEDGE, HENRI; IACOANGELI, ANNA
To: THE RESEARCH FOUNDATION FOR STATE UNIVERSITY OF NEW YORK
Reel/Frame 047486/0392 →
Continuity (3)
Provisional Application
62077725
· Nov 10, 2014