Treating and/or preventing insulin-resistance related weight gain
Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (ACPD).
1. A method of reducing weight gain in a subject in need thereof, the method comprising:
administering an effective amount of 2-acetylcyclopentane-1,3-dione (ACPD) to the subject in need thereof, wherein the subject in need thereof has insulin resistance.
2. The method of claim 1 , wherein the effective amount ranges from about 0.001 mg to about 1,000 mg.
3. The method of claim 1 , wherein the effective amount ranges from about 1 mg/kg bodyweight to about 20 mg/kg body weight.
4. The method of claim 1 , wherein the effective amount is about 10 mg/kg bodyweight.
5. The method of claim 1 , wherein the effective amount is administered in a dosage form formulated for oral, vaginal, intravenous, transdermal, subcutaneous, intraperitoneal, or intramuscular administration.
6. The method of claim 1 , wherein the effective amount reduces weight gain in the subject in need thereof by about 1% to about 50%.
7. The method of claim 1 , wherein the effective amount reduces weight gain in the subject in need thereof by about 25% to about 50%.
8. The method of claim 1 , wherein the effective amount reduces weight gain in the subject in need thereof by about 50%.
9. The method of claim 1 , wherein the reduction in weight gain is not the result of decreased food intake by the subject in need thereof.