FOOD SUPPLEMENT FOR USE IN A PROCESS OF METABOLIC REBALANCING
A composition for a food supplement comprising a substance capable of exerting an anti-oedemigenous and/or anti-inflammatory action in soft organic tissues, a substance capable of exerting an antioxidant action and at least one substance facilitating penetration, through a cell membrane, of the substance capable of exerting an anti-oedemigenous and/or anti¬inflammatory action and/or of the substance capable of exerting an antioxidant action, for use in the treatment of female infertility.
1 . A composition for use in the treatment and/or prevention of female infertility, comprising:
bromelain;
at least one substance capable of exerting an antioxidant action, selected from the group consisting of: papain, curcumin and mixtures thereof, and
at least one substance facilitating penetration through a cell membrane, selected from the group consisting of: membrane phospholipids, biopolymers or biocompatible polymers, serum albumin, bovine serum albumin, piperidine and mixtures thereof.
2 . The composition according to claim 1 , for use in the treatment and/or prevention of unexplained female infertility.
3 . The composition according to claim 1 , for use in the treatment and/or prevention of immune-mediated female infertility.
4 . The composition according to claim 1 wherein a total mass of a single unit of administration of said composition has an overall weight between 0.40 grams and 1 gram.
5 . The composition according to claim 1 wherein said membrane phospholipids are selected from among the group consisting of: phosphatidylinositol, phosphatidylethanolamine, phosphatidylcholine, phosphatidylserine and mixtures thereof.
6 . The composition according to claim 1 , wherein said biopolymers or biocompatible polymers are selected from the group consisting of: polyethylene glycol (PEG), polyamide amine/polyacrylic acid (PAA), polycaprolactone (PCL), poly(trimethylene carbonate) (PTMC) and mixtures thereof.
7 . The composition according to claim 1 , wherein said antioxidant substance comprises, per single unit of administration:
papain, in an amount of at least 125 mg by weight; and/or
curcumin, in an amount of at least 131.5 mg by weight.
8 . The composition according to claim 7 , wherein said curcumin is present in phytosome form, said phytosome form comprising curcumin associated with soy phospholipids and/or phosphatidylcholine.
9 . The composition according to claim 1 , wherein the bromelain is present in at least 215 mg by weight per single unit of administration.
10 . The composition according to claim 1 , further comprising at least one substance multiplying absorption and bioavailability of said antioxidant substance, wherein said at least one absorption and bioavailability multiplying substance is selected from the group consisting of membrane phospholipids and wherein said membrane phospholipids are present in a ratio of 5:1 by weight relative to said curcumin in said single unit of administration.
11 . The composition according to claim 1 , further comprising at least one enzyme belonging to the hydrolase family and capable of exerting a fibrinolytic and/or proteolytic action.
12 . The composition according to claim 1 wherein the bromelain and/or said at least one substance capable of exerting an antioxidant action and/or said at least one penetration facilitating substance are present, in a single administration unit, in micrometric and/or nanometric granular form, said nanometric granular form having an average diameter between 0.01 μm and 2 μm.
13 . The composition according to claim 1 , comprising:
curcuma;
papain;
piperidine; and
bromelain
14 . The composition according to claim 13 , comprising:
20.0-30.0% by weight of curcuma, as a dry extract;
20.0-30.0% by weight of papain;
0.1-0.3% by weight, preferably approximately 0.2%, of piperidine, preferably as a dry black pepper extract; and
40.0-50.0% by weight of bromelain 1,200 GDU.
15 . The composition according to claim 13 , wherein curcuma, papain, piperidine and bromelain are present in the following ratios by weight:
papain/piperidine 110-160;
bromelain/piperidine 175-225;
curcuma/piperidine 100-130.
16 . A food supplement for use in the treatment and/or prevention of female infertility comprising the composition according to claim 1 and at least one physiologically acceptable excipient.
17 . The food supplement according to claim 16 , for use in the treatment and/or prevention of unexplained female infertility.
18 . The food supplement according to claim 16 for use in the treatment and/or prevention of immune-mediated female infertility.
19 . The composition according to claim 1 , comprised in tablet or gastro-resistant capsule form.
20 . The supplement according to claim 16 , comprised in tablet or gastro-resistant capsule form.