IP Library › Granted Patent US 10,962,551
Granted Patent B2
US 10,962,551 · App. 15/737,489 · Granted Mar 30, 2021

TDP-43 in degenerative disease

Inventors: Philip C. Wong (Lutherville, MD); Jonathan P. Ling (Baltimore, MD)
Assignee: The Johns Hopkins University
G01N33/6875A61K35/761C07K14/4703C12Q1/6883G01N33/6872A01K2227/105A01K2267/0356A61K38/00C07K2319/00C12Q2600/158G01N2333/4704G01N2800/28
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Quick Facts
Patent No.
US 10,962,551
App. No.
15/737,489
Granted
Mar 30, 2021
Kind
B2
Abstract

Chimeric proteins comprising an N-terminal domain derived from an N-terminal nucleotide binding domain of TDP-43 and a C-terminal domain derived from a splicing repressor are described. These proteins may be administered to a subject to treat or prevent disease manifesting TDP-43 proteinopathy such as inclusion body myocytosis, amyotrophic lateral sclerosis (ALS), or frontotemporal dementia (FTD).

Claims (1)

1. A chimeric protein comprising the amino acid sequence encoded by SEQ ID NO:13.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 21, 2020
From: WONG, PHILIP C.; LING, JONATHAN P.
To: THE JOHNS HOPKINS UNIVERSITY
Reel/Frame 053271/0407 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 28, 2019
From: WONG, PHILIP C.; LING, JONATHAN P.
To: THE JOHNS HOPKINS UNIVERSITY
Reel/Frame 048722/0923 →
CONFIRMATORY LICENSE Recorded Jan 26, 2018
From: JOHNS HOPKINS UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 045167/0033 →
Continuity (2)
Provisional Application 62180988 · Jun 17, 2015
Related Publication 20180372756A1 · Dec 27, 2018
Cited By (1)
US 12,625,149