Resin-platinum composite and usage thereof
View Patent ↗This resin-platinum composite 100 is provided with resin particles 10 and platinum particles 20 , and the platinum particles 20 are immobilized on the resin particles 10 . In the resin-platinum composite 100 , one portion of the platinum particles 20 may be distributed three-dimensionally on surface layer sections 60 of the resin particles 10 . In this case, the one portion of the three-dimensionally distributed platinum particles 20 may be partially exposed outside the resin particles 10 , and the remaining portion may be enclosed in the resin particles 10 . In the platinum particles 20 , enclosed particles 30 that are fully enclosed in the resin particles 10 , partially exposed particles 40 each having a segment embedded inside the resin particles 10 and a segment exposed outside the resin particles 10 , and surface attached particles 50 attached to the surfaces of the resin particles 10 preferably exist.
1. A resin-platinum composite comprising:
a resin particle; and
a plurality of platinum particles that are relatively smaller than the resin particle,
wherein the plurality of platinum particles are fixed to the resin particle,
60 wt % to 100 wt % of the plurality of platinum particles are in a surface layer section of the resin particle,
at least some of the platinum particles are distributed three-dimensionally in the surface layer section of the resin particle,
the resin particle is a polymer particle having, in a repeating unit of the polymer, a substituent to which platinum ions are able to be attached, wherein the polymer is selected from the group consisting of polyamine, polyamide, polyimide, polypyrrole, and an acrylic resin having a nitrogen atom in a side chain thereof,
the platinum particles consist of platinum,
an average particle size of the platinum particles is in a range of 3 to 30 nm,
an average particle size of the resin-platinum composite is in a range of 100-600 nm,
a supported amount of the platinum particles is in a range of 5 wt % to 70 wt % with respect to a weight of the resin-platinum composite, and
20 wt % or less of the platinum particles are surface-attached particles.
2. The resin-platinum composite according to claim 1 , wherein the average particle size of the platinum particles is in a range of 5 to 30 nm.
3. The resin-platinum composite according to claim 1 , wherein an average particle size of the platinum particles is in a range of 3 to 15 nm.
4. The resin-platinum composite according to claim 1 , wherein the supported amount of the platinum particles is in a range of 15 wt % to 60 wt % with respect to the weight of the resin-platinum composite.
5. A labeling substance comprising the resin-platinum composite according to claim 1 .
6. The labeling substance according to claim 5 that is used by attaching an antigen or an antibody to the surface of the resin-platinum composite.
7. An immunological measurement method using the labeling substance according to claim 5 .
8. A reagent for immunological measurement comprising the resin-platinum composite according to claim 1 .
9. An analyte measurement method of detecting or quantifying an analyte contained in a sample, the analyte measurement method comprising performing the following Processes (I) to (III) using a test strip for lateral flow chromatography that comprises a membrane and a determination section to which a capture ligand that specifically binds to the analyte is fixed in the membrane:
Process (I): a process of contacting the analyte contained in the sample with a labeled antibody obtained by labeling an antibody that specifically binds to the analyte with the resin-platinum composite according to claim 1 ;
Process (II): a process of contacting a composite comprising the analyte and the labeled antibody formed in Process (I) with the capture ligand in the determination section; and
Process (III): a process of measuring a color development intensity derived from localized surface plasmon resonance and light energy absorption due to electron transition of the resin-platinum composite.
10. An analyte measurement kit for detecting or quantifying an analyte contained in a sample using a test strip for lateral flow chromatography, the analyte measurement kit comprising:
the test strip for lateral flow chromatography that comprises a membrane and a determination section to which a capture ligand that specifically binds to the analyte is fixed in the membrane; and
a detection reagent comprising a labeled antibody obtained by labeling an antibody that specifically binds to the analyte with the resin-platinum composite according to claim 1 .
11. A test strip for lateral flow chromatography for detecting or quantifying an analyte contained in a sample, the test strip for lateral flow chromatography comprising:
a membrane;
a determination section to which a capture ligand that specifically binds to the analyte is fixed in a direction in which the sample is developed in the membrane; and
a reaction section that is upstream from the determination section and comprises a labeled antibody obtained by labeling an antibody that specifically binds to the analyte with the resin-platinum composite according to claim 1 .