IP Library › Granted Patent US 10,105,348
Granted Patent B2
US 10,105,348 · App. 15/743,522 · Granted Oct 23, 2018

Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the treatment of seizures

Inventors: Liga Zvejniece (Marupe, LV); Maija Dambrova (Riga, LV); Baiba Svalbe (Sigulda, LV); Edijs Vavers (Incukalns, LV); Ivars Kalvins (Ikskile, LV); Grigorijs Veinbergs (Riga, LV); Ilmars Stonans (Riga, LV); Ilga Misane (Riga, LV); Maksims Vorona (Riga, LV); Aleksandrs Cernobrovijs (Riga, LV)
Assignee: Latvian Institute of Organic Synthesis
A61K31/4015A61P25/08
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,105,348
App. No.
15/743,522
Granted
Oct 23, 2018
Kind
B2
Abstract

Use of 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.

Claims (6)

1. A method for the prophylaxis or treatment of seizure, comprising administering to an individual in need thereof a pharmaceutically effective amount of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide (I)

or a pharmaceutically acceptable salt thereof or a pharmaceutically effective amount of a pharmaceutical composition comprising 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, additive, diluent, cryoprotective or lyoprotective agent.

2. The method of claim 1 , wherein the seizure is epileptic seizure.

3. The method of claim 1 , wherein the seizure is tonic seizure.

4. The method of claim 1 , wherein the seizure is clonic seizure.

5. The method of claim 1 , wherein the administration is oral, parenteral, intravenous, intramuscular, epidural, intrathecal, inhalative, or topical administration.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 19, 2026
From: LATVIAN INSTITUTE OF ORGANIC SYNTHESIS
To: NATIONAL INSTITUTE OF RESEARCH AND INNOVATION
Reel/Frame 075708/0308 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2018
From: ZVEJNIECE, LIGA; DAMBROVA, MAIJA; SVALBE, BAIBA; VAVERS, EDIJS; KALVINS, IVARS; VEINBERGS, GRIGORIJS; STONANS, ILMARS; MISANE, ILGA; VORONA, MAKSIMS; CERNOBROVIJS, ALEKSANDRS
To: LATVIAN INSTITUTE OF ORGANIC SYNTHESIS
Reel/Frame 045659/0171 →
Priority Claims (1)
EP 15179448 · Aug 3, 2015 · regional
Continuity (1)
Related Publication 20180200227A1 · Jul 19, 2018