Protein acyl transferase inhibitors and methods of treatment
Embodiments of the present disclosure include compositions and pharmaceutical compositions that include protein acyl transferases (PAT) inhibitors, methods of treating a condition or disease, methods of treating autopalmitoylation activity, and the like.
1. A composition, comprising: a compound having the following structure:
wherein each of R1, R2, and R3 is independently selected from the group consisting of:
and
2. The composition of claim 1 , wherein each of R1, R2, and R3 is independently selected from the group consisting of:
3. The composition of claim 1 , wherein R1 is
R2 is
and R3 is
4. The composition of claim 1 , wherein R1 is
R2 is
and R3 is
5. The composition of claim 1 , wherein R1 is
R2 is
and R3 is
6. A pharmaceutical composition comprising a therapeutically effective amount of a compound or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier, to treat a condition, wherein the compound has the following structure:
wherein each of R1, R2, and R3 is independently selected from the group consisting of:
and
7. The pharmaceutical composition of claim 6 , wherein the condition is a disease selected from the group consisting of: colorectal cancer, leukemia, and cervical cancer.
8. The pharmaceutical composition of claim 7 , wherein each of R1, R2, and R3 is independently selected from the group consisting of:
and,
9. The pharmaceutical composition of claim 7 , wherein R1 is
R2 is
and R3 is
10. The pharmaceutical composition of claim 7 , wherein R1 is
R2 is
and R3 is
11. The pharmaceutical composition of claim 7 , wherein R1 is
R2 is
and R3 is
12. A method of treating autopalmitoylation activity, comprising: delivering to a subject in need thereof, a pharmaceutical composition, wherein the pharmaceutical composition includes a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier, wherein the compound has the following structure:
wherein each of R1, R2, and R3 is independently selected from the group consisting of:
and
13. The method of claim 12 , wherein each of R1, R2, and R3 is independently selected from the group consisting of:
and,
14. The method of claim 12 , wherein R1 is
R2 is
and R3 is
15. The method of claim 12 , wherein R1 is
R2 is
and R3 is
16. The method of claim 12 , wherein R1 is
R2 is
and R3 is