Epothilone B and dictyostatin analogs, their preparation and use

1. A compound having the structure:

wherein

Z 1 is —CH 3 or —CF 3 ;

Z 2 is absent or present and when present is —O—;

Z 3 is

Z 4 is —O— of —NH—;

W is alkyl-N 3 , alkyl-SH, C 4 -C 20 alkyl-OH, C 4 -C 20 alkyl-NH 2 , alkyl-NH—R 1 , alkyl-NR 2 R 3 , alkyl-OR 1 , alkyl-OC(O)—R 1 , alkyl-NHAc, alkyl-NHC(O)—R 1 , -alkyl-NHC(O)—R 4 , alkyl-OC(O)—OR 1 , alkyl-NHC(O)—NHR 1 , alkyl-NHC(S)—NHR 1 or alkyl-maleimide,

wherein

R 1 is alkyl-N 3 , alkyl-SH, alkyl-OH, alkyl-NH 2 , or alkyl-maleimide,

R 2 is alkyl-N 3 , alkyl-SH, alkyl-OH, alkyl-NH 2 , or alkyl-maleimide,

R 3 is alkyl-N 3 , alkyl-SH, alkyl-OH, alkyl-NH 2 , or alkyl-maleimide, and

R 4 is alkyl-N 3 , alkyl-SH, alkyl-OH, alkyl-NH 2 or alkyl-maleimide,

α is a bond and is absent or present,

β is a bond and is absent or present,

χ is a bond and is absent or present,

δ is a bond and is absent or present,

wherein when α, β, and Z 2 are present, then χ is absent, and when χ is present, then α, β, and Z 2 are absent

or a stereoisomer or a pharmaceutically acceptable salt or ester thereof.

2. The compound of claim 1 having the structure:

or a stereoisomer or a pharmaceutically acceptable salt or ester thereof.

3. The compound of claim 1 having the structure:

or a stereoisomer or a pharmaceutically acceptable salt or ester thereof.

4. The compound of claim 1 , wherein W is —(CH 2 ) n —N 3 , wherein n is 1-20; or W is —(CH 2 ) n —NHAc, wherein n is 1-20, or a stereoisomer or a pharmaceutically acceptable salt or ester thereof.

5. The compound of claim 1 , wherein W is

wherein n is 1-20, or

wherein n is 4-20.

6. The compound of claim 3 having the structure:

or a stereoisomer or a pharmaceutically acceptable salt or ester thereof.

7. A composition comprising the compound of claim 1 and a carrier.

8. A composition, free of soil extract, comprising the compound of claim 1 .

9. A composition, free of soil extract, comprising at least 1 mg of the compound of claim 1 .