Composition for inhibiting formation of SNARE complex, containing myricetin derivatives
The present invention relates to a composition for inhibiting the formation of a SNARE complex, containing myricetin derivatives, and having novel structures and obtained by the acylation of myricetin, laricitrin, combretol, or syringetin. The myricetin derivatives are considered to exhibit an effect of being bioconverted into myricetin in a cell. The myricetin derivatives lost the dark color of conventional myricetin and properties thereof were changed such that the myricetin derivatives have properties of photostability and fat solubility. Therefore, since stable form myricetin derivatives are absorbed into a cell such that an activity, possessed by normal myricetin, of inhibiting the formation of a SNARE complex are exhibited, the present invention can exhibit an excellent function as a SNARE targeting prodrug, and as a composition for inhibiting the formation of a SNARE complex, containing the same.
1. A method for inhibiting the formation of a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex comprising:
administering one or more compounds selected from compounds represented by Formulae 1a, 1c, and 1e to 1g or a pharmaceutically acceptable salt thereof to a subject suffering from a symptom selected from a group consisting of hyperhidrosis, pore enlargement, and an allergy:
wherein,
each of R 1 ′, R 2 ′, and R 3 ′ is independently linear or branched C 1 -C 4 alkyl, or linear or branched, saturated or unsaturated C 1-20 acyl; and
the alkyls or the acyls are identical to or different from each other.
2. The method of claim 1 , wherein the acyl group is selected from the group consisting of an acetyl group, a butyryl group, an octanoyl group, a lauroyl group, a palmitoyl group, a stearoyl group, and an eicosanoyl group.
3. A method for inhibiting the formation of a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex comprising:
administering a compound represented by Formulae 1 b or a pharmaceutically acceptable salt thereof to a subject suffering from a symptom selected from a group consisting of hyperhidrosis, pore enlargement, and an allergy:
wherein,
R 2 ′ is linear or branched C 2 -C 4 alkyl, or linear or branched, saturated or unsaturated C 1-20 acyl.
4. A method for inhibiting the formation of a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex comprising:
administering a compound represented by Formulae 1b or a pharmaceutically acceptable salt thereof to a subject suffering from a symptom selected from a group consisting of hyperhidrosis and pore enlargement:
wherein,
R 2 ′ is linear or branched C 1 -C 4 alkyl, or linear or branched, saturated or unsaturated C 1-20 acyl.