Treatment and management of augmentation in restless legs syndrome

1. A method of treating Restless Legs Syndrome (RLS), comprising administering to a subject an effective amount of the dopamine D 1 receptor antagonist, ecopipam (SCH 39166).

2. The method of claim 1 , comprising administering to a subject an effective amount of the dopamine D 1 receptor antagonist, ecopipam (SCH 39166) in combination with a D 3 receptor agonist.

3. The method of claim 1 , wherein the subject is at risk for or suffers from augmentation.

4. The method of claim 2 , wherein the D 3 receptor agonist is nafadotride, PD 128907, pramipexole, pergolide, rotigotine, or mixtures thereof

5. The method of claim 4 , wherein the D 3 receptor agonist is pramipexole.

6. The method of claim 1 , wherein the method further comprises administering an opioid receptor agonist.

7. The method of claim 6 , wherein the opioid receptor agonist is allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, clonitazene, codeine, desomorphine, dextromoramide, dezocine, diampromide, diamorphone, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levorphanol, levophenacylmorphan, lofentanil, meperidine, meptazinol, metazocine, methadone, metopon, morphine, myrophine, nalbuphine, narceine, nicomorphine, norlevorphanol, normethadone, nalorphine, normorphine, norpipanone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, phenadoxone, phenomorphan, phenazocine, phenoperidine, piminodine, piritramide, proheptazine, promedol, properidine, propiram, propoxyphene, sufentanil, tilidine, tramadol, or mixtures thereof