(S,E)-3-(6-aminopyridin-3-yl)-N-((5-(4-(3-fluoro-3-methylpyrrolidine-1-carbonyl)phenyl-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide for the treatment of cancer
View Patent ↗The invention generally relates to substituted benzofuranyl compounds and, more particularly, to a compound represented by Structural Formula 1a: (I) or a pharmaceutically acceptable salt thereof. The invention also includes the synthesis and use of the compound of Structural Formula 1a, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of diseases or disorder selected from cancer (e.g., lymphoma, such as mantle cell lymphoma), a neurodegenerative disease, an inflammatory diseases or an immune system disease (e.g., a T-Cell mediated autoimmune disease) in a subject in need thereof. The method comprises administering to a subject in need thereof a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, or a composition comprising a compound of the invention, or a pharmaceutically acceptable salt thereof.
1. A compound represented by Structural Formula Ia:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising:
(a) a compound of claim 1 , or a pharmaceutically acceptable salt thereof; and
(b) a pharmaceutically acceptable carrier.
3. A method of treating a disease or disorder mediated by PAK, NAMPT or both selected from cancer, a neurodegenerative diseases, an inflammatory diseases and autoimmune diseases or an immune system disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof to inhibit PAK, NAMPT or both.
4. The method of claim 3 , wherein the disease or disorder is cancer.
5. The method of claim 4 , wherein the cancer is lymphoma.
6. The method of claim 5 , wherein the lymphoma is mantle cell lymphoma.
7. The method of claim 3 , wherein the disease or disorder is arthritis.
8. The method of claim 3 , wherein the disease or disorder is psoriasis.
9. The method of claim 3 , wherein the disease or disorder is obesity.
10. The method of claim 3 , wherein the disease or disorder is stroke.
11. The method of claim 3 , wherein the disease or disorder is traumatic brain injury.
12. A method of promoting wound healing in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.
13. The method of claim 12 , wherein the wound is a surface wound, a surgical wound, an internal wound, a chronic wound, an ulcer, a burn or a result of radiation exposure.
14. The method of claim 12 , wherein the wound is selected from a burn wound, an incised wound, an open wound, a surgical or post-surgical wound, a diabetic lesion, a thermal burn, a chemical burn, a radiation burn, a pressure sore, a bedsore or a condition related to diabetes or poor circulation.
15. The method of claim 4 , wherein the cancer is cervical cancer.