Intracellular delivery vehicle
An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
1. A compound having a chemical structure represented by general formula (I):
wherein
Y represents a single bond or CHR 85 ,
Z represents a single bond or CHR 86 ,
R 72 and R 73 are each independently selected from C 1-6 alky group,
R 75 , R 76 , R 77 , R 78 , R 85 and R 86 are each independently selected from the group consisting of a hydrogen atom, C 1-6 alkyl group, C 1-6 alkoxy group, C 1-6 alkylcarbonyl group, phenyl group and hydroxyl group, wherein said C 1-6 alkyl group, C 1-6 alkoxy group, C 1-6 alkylcarbonyl group and phenyl group are optionally substituted with 1 or 2 substituents selected from the group consisting of C 1-6 alkyl group, C 1-6 alkoxy group, C 1-6 alkylcarbonyl group, phenyl group and hydroxyl group,
or
R 75 and R 76 or R 77 and R 78 together optionally form —(CH 2 ) 3-5 —,
R 81 , R 82 , R 83 and R 84 are a substituent selected from the group consisting of C 1-4 alkyl group, C 1-4 alkylcarbonyl group and C 1-3 alkoxy group, wherein the C 1-4 alkyl is optionally substituted with one C 1-3 alkoxy group; and
R 71 and R 74 each independently are C 1-3 alkyl group, and
X f − is counter anion.
2. The compound according to claim 1 , wherein said Y and Z represent single bond.
3. The compound according to claim 1 , wherein said R 81 , R 82 , R 83 , and R 84 are each independently selected from the group consisting of methyl group, ethyl group, methylcarbonyl group, isobutyl group, and 2-methyl-2-methoxypropyl group.
4. The compound according to claim 1 , wherein said R 71 and R 74 are a methyl group.
5. The compound according to claim 1 , wherein said R 72 and R 73 , said R 75 and R 77 , said R 76 and R 78 , said R 81 and R 84 , said R 82 and R 83 , and said R 71 and R 74 , each represent an identical substituent, and said Y and Z represent an identical substituent or a single bond.
6. The compound according to claim 1 , wherein said R 71 , R 72 , R 73 , R 74 , R 81 , R 82 , R 83 , and R 84 are a methyl group, and said R 75 , R 76 , R 77 and R 78 are a hydrogen atom, and said Y and Z are a single bond.
7. A cationic polymerization initiator, comprising the compound according to claim 1 .
8. A method for producing an intracellular delivery vehicle, comprising performing a radical polymerization reaction involving the cationic polymerization initiator according to claim 7 , a monomer comprising carbon-carbon double bonds, and a crosslinker.