System for analyzing electrophysiological data and method for analyzing electrophysiological data

1. A system for analyzing electrophysiological data including intracardial electrogram data, the system comprising:

at least one computing device comprising at least one computer readable medium, the computing device being configured to store instructions executable by at least one processor to determine the source and location of at least one cardiac rhythm disorder;

a data output unit comprising a data output screen for displaying results of electrophysiological data analysis,

wherein the computing device is configured to receive electrophysiological data obtained from a mapping catheter assembly comprising an electrode assembly having a plurality of n electrodes, each electrode being configured for measuring electrophysiological data in the form of electrogram signals;

and the computing device is configured to:

(a) assign predetermined positions of electrodes 82 on the electrode assembly to their respective corresponding electrogram signals;

(b) provide or generate a two-dimensional (2D) spatial map of the electrode positions;

(c) for each or selected discrete times over which the electrogram signals are being processed, process the electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2D map, and

(d) process the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map, the velocity vector map being configured to reveal the location of the source of the at least one cardiac rhythm disorder;

and further wherein the data output unit is configured to display the velocity vector map on a data output screen of the data output unit.

2. The system of claim 1 , wherein the computing device is configured to normalize or adjust amplitudes of the electrogram signals.

3. The system of claim 2 , wherein the computing device is configured to high-pass-filter the normalized and/or adjusted electrogram signals.

4. to the system of claim 1 , wherein computing device is configured to generate the plurality of three-dimensional electrogram surfaces using Green's function.

5. The system of claim 1 , wherein the computing device is configured to process the plurality of three-dimensional electrogram surfaces through time to generate the velocity vector map using optical flow analysis techniques.

6. The system of claim 1 , wherein at least portions of the electrogram surfaces generated by the computing device are configured to correspond to estimated wave shapes or wavefronts.

7. The system of claim 1 , wherein electrogram surfaces are generated by the computing device using a two-dimensional bi-harmonic spline interpolation function.

8. The system of claim 1 , wherein the computing device is configured to process sets of electrophysiological data associated with time slices representing electrogram signal amplitude values and to generate a series of vector data representing the average speed and direction of movement of clusters of electrophysiological data.

9. The system of claim 1 , wherein the data output unit is configured to display passive and active rotors by means of the vector data that are displayed on the data output screen of the data output unit.

10. The system of claim 1 , wherein the data output screen is configured to display vector data in form of vector arrows, the data vector arrows representing action potential wave maps.

11. The system of claim 1 , wherein the computing device is configured to process electrophysiological data using at least one data analysis method selected from the group consisting of a phase correlation method, a block-based method, a discrete optimization method, and a differential method of estimating optical flow including the Lucas-Kanade method, the Horn-Schunck method, the Buxton-Buxton method, and the Black-Jepson method, or any variations or combinations thereof.

12. A method of analyzing electrophysiological data, including action potential data, the method comprising the steps of: measuring electrophysiological data with a plurality of mapping electrodes disposed at a distal end of an elongated medical device,

receiving, at a computing device, the action potential data from the plurality of mapping electrodes;

assigning, in the computing device predetermined positions of electrodes on the electrode assembly to their respective corresponding electrogram signals;

generating, in the computing device, a two-dimensional (2D) spatial map of the electrode positions;

for each or selected discrete times over which the electrogram signals are being processed in the computing device, processing the electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2D map; and

processing, in the computing device, the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map, the velocity vector map being configured to reveal the location of the source of at least one cardiac rhythm disorder, and

displaying the vector data on a data output screen of the data output unit.

13. The method of claim 12 , wherein the velocity vector map comprises data arrows representing action potential wave maps.

14. The method of claim 12 , wherein the plurality of three-dimensional electrogram surfaces is generated in computing device using Green's function.

15. The method of claim 12 , wherein the plurality of three-dimensional electrogram surfaces is processed through time in the computing device to generate the velocity vector map using optical flow analysis techniques.

16. The method of claim 15 , wherein the optical flow analysis is performed on sets of electrophysiological data associated with time slices comprising virtual and measured electrogram signals including their respective amplitude values to generate a series of vector data representing the average speed and direction of the movement of clusters of electrophysiological data.

17. The method of claim 12 , wherein the electrogram signals are normalized or adjusted before the three-dimensional electrogram surfaces are generated..

18. The method of claim 12 , wherein the electrogram signals are band-pass-filtered before the three-dimensional electrogram surfaces are -generated.

19. The method of claim 12 , wherein at least portions of the electrogram surfaces generated by the computing device correspond to estimated wave shapes or wavefronts.

20. The method of claim 12 , wherein the computing device generates the electrogram surfaces using a two-dimensional bi-harmonic spline interpolation function.

21. The method of claim 12 , wherein the computing device is configured to process electrophysiological data using at least one data analysis method selected from the group consisting of a phase correlation method, a block-based method, a discrete optimization method, and a differential method of estimating optical flow, including the Lucas-Kanade method, the Horn-Schunck method, the Buxton-Buxton method and the Black-Jepson method, or any variations or combinations thereof.