IP Library › Granted Patent US 10,449,234
Granted Patent B2
US 10,449,234 · App. 15/759,203 · Granted Oct 22, 2019

Compositions and methods for prevention and treatment of corneal haze and scarring

Inventors: Sunil Chauhan (Cambridge, MA); Reza Dana (Newton, MA)
Assignee: The Schepens Eye Research Institute, Inc.
A61K38/1833A61K9/0048A61P27/02C07K14/00C07K14/4753
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Quick Facts
Patent No.
US 10,449,234
App. No.
15/759,203
Granted
Oct 22, 2019
Kind
B2
Abstract

This application discloses ophthalmic formulations and methods for treating and preventing corneal haze and scarring with an hepatocyte growth factor (HGF) agent.

Claims (8)

1. A method of treating corneal haze or scarring comprising administering a composition comprising the purified hepatocyte growth factor (HGF) polypeptide of SEQ ID NO: 1 to a subject in need thereof, where the composition is topically administered to the cornea and the corneal haze or scarring is reduced in severity.

2. The method of claim 1 , wherein the purified HGF agent is present in a concentration of 0.001% to 1% w/v.

3. The method of claim 1 , wherein the HGF polypeptide is present in a concentration of about 0.005% to 0.05% w/v.

4. The method of claim 1 , wherein the HGF polypeptide is present in a concentration of about 0.01% w/v.

5. The method of claim 1 , wherein the composition is administered daily for 5 days after an injury to the cornea.

6. The method of claim 1 , wherein the composition is administered daily for 3 days after an injury to the cornea.

7. The method of claim 1 , wherein the composition is administered daily for 1 day after an injury to the cornea.

8. The method of claim 1 , wherein the composition is formulated as an eye drop.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 21, 2025
From: THE SCHEPENS EYE RESEARCH INSTITUTE, INC.
To: MASSACHUSETTS EYE AND EAR INFIRMARY
Reel/Frame 070593/0159 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 19, 2018
From: CHAUHAN, SUNIL; DANA, REZA
To: THE SCHEPENS EYE RESEARCH INSTITUTE, INC.
Reel/Frame 047543/0777 →
Continuity (2)
Provisional Application 62217611 · Sep 11, 2015
Related Publication 20180256685A1 · Sep 13, 2018