DEVICE FOR THE REGIONAL ANTICOAGULATION
A device for regional anticoagulation by citrate-Calcium, of the type usable in a circuit which comprises a first duct or blood line ( 2 ) provided with an inlet ( 1 ) to withdraw blood from the patient and a downstream outlet ( 7 ) for return the treated blood to the patient, device characterized in that it is arranged on said blood line ( 2 ) and is provided with a membrane made of a material adapted to bind with the Citrate.
1 . A device for regional anticoagulation by Citrate-Calcium, provided with an input ( 101 ) for the blood to be treated and an outlet ( 102 ) for the treated blood, characterized in that it is provided with a membrane made of a material able to bind with the Citrate.
2 . Device according to claim 1 , characterized in that said membrane is made of a material suitable to bind with trisodium citrate.
3 . Device according to claim 1 , characterized in that said membrane is made of a material to bind with citrate with covalent bond.
4 . Device according to claim 1 , characterized in that said membrane is made of graphene or oxidized graphite.
5 . Device according to claim 1 , characterized in that said membrane is made of graphene or oxidized graphite, via oxidation by determining bonds with oxygen in the form of carboxyl (COOH), with subsequent treatment with thionyl chloride (SOCl) adapted to transform Device molecules in acid chlorides (GO—COCl).
6 . Device according to clam 1 , characterized in that said membrane is made of a material selected from the group consisting of: alumina or functionalized silica, agar, gel having a composition suitable to bind with the Citrate.
7 . Extracorporeal blood circuit, comprising a first duct or blood line ( 2 ) provided with an inlet ( 1 ) to withdraw blood from the patient and a downstream outlet ( 7 ) to return the treated blood to the patient, characterized in that it comprises a device ( 10 ) disposed on said blood line ( 2 ) and provided with a membrane made of a material adapted to bind with the citrate.
8 . Circuit according to claim 7 , characterized in that it said membrane is made of a material suitable to bind with trisodium citrate.
9 . A circuit according to claim 7 , characterized in that said membrane is made of a material suitable to bind citrate with a covalent bond.
10 . Circuit according to claim 7 , characterized in that it said membrane is made of graphene or oxidized graphite.
11 . Circuit according to claim 7 , characterized in that it said membrane is made of graphene or oxidized graphite, via oxidation by determining bonds with oxygen in the form of carboxyl (COOH), with subsequent treatment with thionyl chloride (SOCl2) adapted to transform Device molecules in acid chlorides (GO—COCl).
12 . Circuit according to claim 7 , characterized in that said membrane is made of one or more materials selected from the group consisting of, alumina or functionalized silica,
agar, gel having a composition suitable to bind with the Citrate.
13 . Circuit according to claim 7 , wherein the circuit comprises a blood pump ( 4 ) arranged downstream of said inlet ( 1 ) and upstream of said outlet ( 7 ), characterized in that the device ( 10 ) is arranged upstream of said pump ( 4 ).
14 . Device according to claim 7 , wherein the circuit comprises a blood pump ( 4 ) arranged downstream of said inlet ( 1 ) and upstream of said outlet ( 7 ), characterized in that the device ( 10 ) is arranged downstream of said pump ( 4 ).